Carbonylporphyrins and uses thereof
Abstract
The present invention is directed to low toxicity boronated compounds and methods for their use in the treatment, visualization, and diagnosis of tumors. More specifically, the present invention is directed to low toxicity carborane-containing porphyrin compounds with halide, amine, or nitro groups and methods for their use particularly in boron neutron capture therapy (BNCT), X-ray radiation therapy (XRT), and photodynamic therapy (PDT) for the treatment of tumors of the brain, head and neck, and surrounding tissue. The invention is also directed to using these carborane-containing porphyrin compounds in methods of tumor imaging and/or diagnosis such as MRI, SPECT, or PET.
- Inventors:
- Issue Date:
- Research Org.:
- Brookhaven National Laboratory (BNL), Upton, NY (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1128515
- Patent Number(s):
- 8673265
- Application Number:
- 13/608,305
- Assignee:
- Brookhaven Science Associates, LLC (Upton, NY)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- DOE Contract Number:
- AC02-98CH10886
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 62 RADIOLOGY AND NUCLEAR MEDICINE
Citation Formats
Miura, Michiko, and Renner, Mark W. Carbonylporphyrins and uses thereof. United States: N. p., 2014.
Web.
Miura, Michiko, & Renner, Mark W. Carbonylporphyrins and uses thereof. United States.
Miura, Michiko, and Renner, Mark W. Tue .
"Carbonylporphyrins and uses thereof". United States. https://www.osti.gov/servlets/purl/1128515.
@article{osti_1128515,
title = {Carbonylporphyrins and uses thereof},
author = {Miura, Michiko and Renner, Mark W},
abstractNote = {The present invention is directed to low toxicity boronated compounds and methods for their use in the treatment, visualization, and diagnosis of tumors. More specifically, the present invention is directed to low toxicity carborane-containing porphyrin compounds with halide, amine, or nitro groups and methods for their use particularly in boron neutron capture therapy (BNCT), X-ray radiation therapy (XRT), and photodynamic therapy (PDT) for the treatment of tumors of the brain, head and neck, and surrounding tissue. The invention is also directed to using these carborane-containing porphyrin compounds in methods of tumor imaging and/or diagnosis such as MRI, SPECT, or PET.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Mar 18 00:00:00 EDT 2014},
month = {Tue Mar 18 00:00:00 EDT 2014}
}
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Works referenced in this record:
Chelation of charged and uncharged molecules with porphyrin-based compounds
patent-application, June 2004
- Vincente, Maria da Graca Henriques
- US Patent Application 10/712513; 20040106592
Carboranylporphyrins and uses Thereof
patent-application, November 2005
- Wu, Haitao; Miura, Michiko
- US Patent Application 10/848741; 20050260128
Functionalization of 5,15-Diphenylporphyrin: Preparation and X-Ray Crystal Structures of meso Nitro, Bromo, and Trimethylsilylethynyl Derivatives
journal, January 1997
- Arnold, Dennis P.; Bott, Raymond C.; Eldridge, Helen
- Australian Journal of Chemistry, Vol. 50, Issue 5