Carbonylporphyrins and uses thereof

Title: Carbonylporphyrins and uses thereof

Abstract

The present invention is directed to low toxicity boronated compounds and methods for their use in the treatment, visualization, and diagnosis of tumors. More specifically, the present invention is directed to low toxicity carborane-containing porphyrin compounds with halide, amine, or nitro groups and methods for their use particularly in boron neutron capture therapy (BNCT), X-ray radiation therapy (XRT), and photodynamic therapy (PDT) for the treatment of tumors of the brain, head and neck, and surrounding tissue. The invention is also directed to using these carborane-containing porphyrin compounds in methods of tumor imaging and/or diagnosis such as MRI, SPECT, or PET.

Inventors:: Miura, Michiko; Renner, Mark W

Issue Date:: 2014-03-18

Research Org.:: BNL (Brookhaven National Laboratory (BNL), Upton, NY (United States))

Sponsoring Org.:: USDOE

OSTI Identifier:: 1128515

Patent Number(s):: 8,673,265

Application Number:: 13/608,305

Assignee:: Brookhaven Science Associates, LLC (Upton, NY)

DOE Contract Number:: AC02-98CH10886

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE

Citation Formats


                    Miura, Michiko, and Renner, Mark W. Carbonylporphyrins and uses thereof.  United States: N. p., 2014. 
        Web.

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                    Miura, Michiko, & Renner, Mark W. Carbonylporphyrins and uses thereof.  United States.

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                    Miura, Michiko, and Renner, Mark W. Tue .  
        "Carbonylporphyrins and uses thereof".  United States.  https://www.osti.gov/servlets/purl/1128515.

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@article{osti_1128515,

  title        = {Carbonylporphyrins and uses thereof},

  author       = {Miura, Michiko and Renner, Mark W},

  abstractNote = {The present invention is directed to low toxicity boronated compounds and methods for their use in the treatment, visualization, and diagnosis of tumors. More specifically, the present invention is directed to low toxicity carborane-containing porphyrin compounds with halide, amine, or nitro groups and methods for their use particularly in boron neutron capture therapy (BNCT), X-ray radiation therapy (XRT), and photodynamic therapy (PDT) for the treatment of tumors of the brain, head and neck, and surrounding tissue. The invention is also directed to using these carborane-containing porphyrin compounds in methods of tumor imaging and/or diagnosis such as MRI, SPECT, or PET.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2014},

  month        = {3}

}

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Works referenced in this record:

Carboranylporphyrins and uses Thereof
patent-application, November 2005

Wu, Haitao; Miura, Michiko
US Patent Application 10/848741; 20050260128
URL: http://appft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050260128%22.PGNR.&OS=DN/20050260128&RS=DN/20050260128

Functionalization of 5,15-Diphenylporphyrin: Preparation and X-Ray Crystal Structures of meso Nitro, Bromo, and Trimethylsilylethynyl Derivatives
journal, January 1997

Arnold, Dennis P.; Bott, Raymond C.; Eldridge, Helen
Australian Journal of Chemistry, Vol. 50, Issue 5
DOI: 10.1071/C96193

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Similar Records

Title: Carbonylporphyrins and uses thereof

Abstract

Citation Formats

Carboranylporphyrins and uses Thereof patent-application, November 2005

Functionalization of 5,15-Diphenylporphyrin: Preparation and X-Ray Crystal Structures of meso Nitro, Bromo, and Trimethylsilylethynyl Derivatives journal, January 1997

Carboranylporphyrins and uses Thereof
patent-application, November 2005

Functionalization of 5,15-Diphenylporphyrin: Preparation and X-Ray Crystal Structures of meso Nitro, Bromo, and Trimethylsilylethynyl Derivatives
journal, January 1997