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Title: Method of tissue repair using a composite material

Abstract

A composite biocompatible hydrogel material includes a porous polymer matrix, the polymer matrix including a plurality of pores and providing a Young's modulus of at least 10 GPa. A calcium comprising salt is disposed in at least some of the pores. The porous polymer matrix can comprise cellulose, including bacterial cellulose. The composite can be used as a bone graft material. A method of tissue repair within the body of animals includes the steps of providing a composite biocompatible hydrogel material including a porous polymer matrix, the polymer matrix including a plurality of pores and providing a Young's modulus of at least 10 GPa, and inserting the hydrogel material into cartilage or bone tissue of an animal, wherein the hydrogel material supports cell colonization in vitro for autologous cell seeding.

Inventors:
; ; ;
Issue Date:
Research Org.:
ORNL (Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States))
Sponsoring Org.:
USDOE
OSTI Identifier:
1127166
Patent Number(s):
8,673,337
Application Number:
13/340,114
Assignee:
UT-Battelle, LLC (Oak Ridge, TN); University of Tennessee Research Foundation (Knoxville, TN)
DOE Contract Number:  
AC05-000R22725
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE

Citation Formats

Hutchens, Stacy A, Woodward, Jonathan, Evans, Barbara R, and O'Neill, Hugh M. Method of tissue repair using a composite material. United States: N. p., 2014. Web.
Hutchens, Stacy A, Woodward, Jonathan, Evans, Barbara R, & O'Neill, Hugh M. Method of tissue repair using a composite material. United States.
Hutchens, Stacy A, Woodward, Jonathan, Evans, Barbara R, and O'Neill, Hugh M. Tue . "Method of tissue repair using a composite material". United States. https://www.osti.gov/servlets/purl/1127166.
@article{osti_1127166,
title = {Method of tissue repair using a composite material},
author = {Hutchens, Stacy A and Woodward, Jonathan and Evans, Barbara R and O'Neill, Hugh M},
abstractNote = {A composite biocompatible hydrogel material includes a porous polymer matrix, the polymer matrix including a plurality of pores and providing a Young's modulus of at least 10 GPa. A calcium comprising salt is disposed in at least some of the pores. The porous polymer matrix can comprise cellulose, including bacterial cellulose. The composite can be used as a bone graft material. A method of tissue repair within the body of animals includes the steps of providing a composite biocompatible hydrogel material including a porous polymer matrix, the polymer matrix including a plurality of pores and providing a Young's modulus of at least 10 GPa, and inserting the hydrogel material into cartilage or bone tissue of an animal, wherein the hydrogel material supports cell colonization in vitro for autologous cell seeding.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2014},
month = {3}
}

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