Compositions of orthogonal lysyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof
Abstract
Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal lysyl-tRNAs, orthogonal lysyl-aminoacyl-tRNA synthetases, and orthogonal pairs of lysyl-tRNAs/synthetases, which incorporate homoglutamines into proteins are provided in response to a four base codon. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with homoglutamines using these orthogonal pairs.
- Inventors:
- Issue Date:
- Research Org.:
- The Scripps Research Institute, La Jolla, CA, USA
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1126706
- Patent Number(s):
- 8669073
- Application Number:
- 13/246,490
- Assignee:
- The Scripps Research Institute (La Jolla, CA)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
- DOE Contract Number:
- ER45812
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Anderson, J. Christopher, Wu, Ning, Santoro, Stephen, and Schultz, Peter G. Compositions of orthogonal lysyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof. United States: N. p., 2014.
Web.
Anderson, J. Christopher, Wu, Ning, Santoro, Stephen, & Schultz, Peter G. Compositions of orthogonal lysyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof. United States.
Anderson, J. Christopher, Wu, Ning, Santoro, Stephen, and Schultz, Peter G. Tue .
"Compositions of orthogonal lysyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof". United States. https://www.osti.gov/servlets/purl/1126706.
@article{osti_1126706,
title = {Compositions of orthogonal lysyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof},
author = {Anderson, J. Christopher and Wu, Ning and Santoro, Stephen and Schultz, Peter G},
abstractNote = {Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal lysyl-tRNAs, orthogonal lysyl-aminoacyl-tRNA synthetases, and orthogonal pairs of lysyl-tRNAs/synthetases, which incorporate homoglutamines into proteins are provided in response to a four base codon. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with homoglutamines using these orthogonal pairs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2014},
month = {3}
}
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