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Title: Peptides whose uptake by cells is controllable

Abstract

A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A portion includes acidic amino acids. The intact structure is not significantly taken up by cells; however, upon extracellular cleavage of X, the B-C portion is taken up, delivering the cargo to targeted cells. Cargo may be, for example, a contrast agent for diagnostic imaging, a chemotherapeutic drug, or a radiation-sensitizer for therapy. Cleavage of X allows separation of A from B, unmasking the normal ability of the basic amino acids in B to drag cargo C into cells near the cleavage event. X is cleaved extracellularly, preferably under physiological conditions. D-amino acids are preferred for the A and B portions, to minimize immunogenicity and nonspecific cleavage by background peptidases or proteases.

Inventors:
;
Issue Date:
Research Org.:
The Regents of the University of California, Oakland, CA, USA
Sponsoring Org.:
USDOE
OSTI Identifier:
1118269
Patent Number(s):
8642561
Application Number:
13/314,134
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
DOE Contract Number:  
FG03-01ER63276
Resource Type:
Patent
Resource Relation:
Patent File Date: 2011 Dec 07
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Jiang, Tao, and Tsien, Roger Y. Peptides whose uptake by cells is controllable. United States: N. p., 2014. Web.
Jiang, Tao, & Tsien, Roger Y. Peptides whose uptake by cells is controllable. United States.
Jiang, Tao, and Tsien, Roger Y. Tue . "Peptides whose uptake by cells is controllable". United States. https://www.osti.gov/servlets/purl/1118269.
@article{osti_1118269,
title = {Peptides whose uptake by cells is controllable},
author = {Jiang, Tao and Tsien, Roger Y},
abstractNote = {A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A portion includes acidic amino acids. The intact structure is not significantly taken up by cells; however, upon extracellular cleavage of X, the B-C portion is taken up, delivering the cargo to targeted cells. Cargo may be, for example, a contrast agent for diagnostic imaging, a chemotherapeutic drug, or a radiation-sensitizer for therapy. Cleavage of X allows separation of A from B, unmasking the normal ability of the basic amino acids in B to drag cargo C into cells near the cleavage event. X is cleaved extracellularly, preferably under physiological conditions. D-amino acids are preferred for the A and B portions, to minimize immunogenicity and nonspecific cleavage by background peptidases or proteases.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2014},
month = {2}
}

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Peptides whose uptake by cells is controllable
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Peptides whose uptake by cells is controllable
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patent-application, December 2004


Peptides whose uptake by cells is controllable
patent-application, May 2005


Peptides whose uptake by cells is controllable
patent-application, February 2006


Peptides whose uptake by cells is controllable
patent-application, February 2007


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    Works referencing / citing this record:

    Peptides whose uptake in cells is controllable
    patent, June 2017


    Selective delivery molecules and methods of use
    patent, November 2016


    Selective delivery molecules and methods of use
    patent, June 2016


    Selective delivery molecules and methods of use
    patent, March 2016


    Peptides whose uptake by cells is controllable
    patent, July 2015