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Title: Group specific internal standard technology (GSIST) for simultaneous identification and quantification of small molecules

Abstract

Reagents and methods are provided that permit simultaneous analysis of multiple diverse small molecule analytes present in a complex mixture. Samples are labeled with chemically identical but isotopically distince forms of the labeling reagent, and analyzed using mass spectrometry. A single reagent simultaneously derivatizes multiple small molecule analytes having different reactive functional groups.

Inventors:
; ;
Issue Date:
Research Org.:
Purdue Research Foundation, West Lafayette, IN, USA
Sponsoring Org.:
USDOE
OSTI Identifier:
1117679
Patent Number(s):
8628977
Application Number:
12/990,560
Assignee:
Purdue Research Foundation (West Lafayette, IN)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
DOE Contract Number:  
FC36-07GO17059
Resource Type:
Patent
Resource Relation:
Patent File Date: 2009 May 01
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Adamec, Jiri, Yang, Wen-Chu, and Regnier, Fred E. Group specific internal standard technology (GSIST) for simultaneous identification and quantification of small molecules. United States: N. p., 2014. Web.
Adamec, Jiri, Yang, Wen-Chu, & Regnier, Fred E. Group specific internal standard technology (GSIST) for simultaneous identification and quantification of small molecules. United States.
Adamec, Jiri, Yang, Wen-Chu, and Regnier, Fred E. Tue . "Group specific internal standard technology (GSIST) for simultaneous identification and quantification of small molecules". United States. https://www.osti.gov/servlets/purl/1117679.
@article{osti_1117679,
title = {Group specific internal standard technology (GSIST) for simultaneous identification and quantification of small molecules},
author = {Adamec, Jiri and Yang, Wen-Chu and Regnier, Fred E},
abstractNote = {Reagents and methods are provided that permit simultaneous analysis of multiple diverse small molecule analytes present in a complex mixture. Samples are labeled with chemically identical but isotopically distince forms of the labeling reagent, and analyzed using mass spectrometry. A single reagent simultaneously derivatizes multiple small molecule analytes having different reactive functional groups.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2014},
month = {1}
}

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