High molecular weight polysaccharide that binds and inhibits virus

Konowalchuk, Thomas W

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Title: High molecular weight polysaccharide that binds and inhibits virus

Abstract

This invention provides a high molecular weight polysaccharide capable of binding to and inhibiting virus and related pharmaceutical formulations and methods on inhibiting viral infectivity and/or pathogenicity, as well as immunogenic compositions. The invention further methods of inhibiting the growth of cancer cells and of ameliorating a symptom of aging. Additionally, the invention provides methods of detecting and/or quantifying and/or isolating viruses.

Inventors:: Konowalchuk, Thomas W

Issue Date:: Tue Jan 14 00:00:00 EST 2014

Research Org.:: World Force Technologies, LLC, Newport, OR, USA

Sponsoring Org.:: USDOE

OSTI Identifier:: 1117665

Patent Number(s):: 8629121

Application Number:: 12/694,226

Assignee:: World Force Technologies, LLC (Newport, OR)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K2300/00 - Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
A61K31/353 - 3,4-Dihydrobenzopyrans, e.g. chroman, catechin
A61K31/715 - Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages
A61K36/87 - Vitaceae or Ampelidaceae
A61K9/0014 - {Skin, i.e. galenical aspects of topical compositions
A61K9/0095 - {Drinks

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P31/12 - Antivirals
A61P37/00 - Drugs for immunological or allergic disorders

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C12N7/00 - Viruses

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N33/56983 - {Viruses}

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DOE Contract Number:: FG09-93ER20097

Resource Type:: Patent

Resource Relation:: Patent File Date: 2010 Jan 26

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES

Citation Formats


                    Konowalchuk, Thomas W. High molecular weight polysaccharide that binds and inhibits virus.  United States: N. p., 2014. 
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                    Konowalchuk, Thomas W. High molecular weight polysaccharide that binds and inhibits virus.  United States.

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                    Konowalchuk, Thomas W. Tue .  
        "High molecular weight polysaccharide that binds and inhibits virus".  United States.  https://www.osti.gov/servlets/purl/1117665.

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@article{osti_1117665,

  title        = {High molecular weight polysaccharide that binds and inhibits virus},

  author       = {Konowalchuk, Thomas W},

  abstractNote = {This invention provides a high molecular weight polysaccharide capable of binding to and inhibiting virus and related pharmaceutical formulations and methods on inhibiting viral infectivity and/or pathogenicity, as well as immunogenic compositions. The invention further methods of inhibiting the growth of cancer cells and of ameliorating a symptom of aging. Additionally, the invention provides methods of detecting and/or quantifying and/or isolating viruses.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Jan 14 00:00:00 EST 2014},

  month        = {Tue Jan 14 00:00:00 EST 2014}

}

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Works referenced in this record:

Acidic polysaccharide CH-1 isolated from Chlorella pyrenoidosa and the use thereof
patent, August 1985

Umezawa, Iwao; Komiyama, Kanki
US Patent Document 4,533,548
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4533548

Plant extract with a proanthocyanidins content as therapeutic agent having radical scavenger effect and use thereof
patent, October 1987

Masquelier, Jack
US Patent Document 4,698,360
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4698360

Proanthocyanidin polymers having antiviral activity and methods of obtaining same
patent, May 1993

Tempesta, Michael S.
US Patent Document 5,211,944
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5211944

Process for preparing grapeseed extracts enriched in procyanidol oligomers
patent, January 1996

Frangi, Enrico; Bertani, Marco; Mustich, Giuseppe
US Patent Document 5,484,594
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5484594

Antiviral polysaccharide
patent, December 1996

Hayashi, Toshimitsu; Hayashi, Kyoko; Kojima, Ichiro
US Patent Document 5,585,365
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5585365

Immunogenic polypeptides that mimic a surface polysaccharide antigen of a pathogenic microorganism, method for obtaining the same, and their use in vaccine compositions
patent, March 2003

Phalipon, Armelle; Sansonetti, Philippe; Felici, Franco
US Patent Document 6,528,061
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6528061

Modified polysaccharide adjuvant-protein antigen conjugates, the preparation thereof and the use thereof
patent, June 2003

Marciani, Dante J.
US Patent Document 6,573,245
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6573245

High molecular weight polysaccharide fraction from aloe vera with immunostimulatory activity
patent-application, February 2004

Elsobly, Mahmoud; Ross, Samir; Pasco, David Stanley
US Patent Application 10/332408; 20040038931
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20040038931

Lipid-regulating agent and use thereof
patent-application, December 2006

Oku, Kazuyuki; Kubota, Michio; Fukuda, Shigeharu
US Patent Application 10/551765; 20060276432
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20060276432

Carbohydrate analysis by high-performance anion-exchange chromatography with pulsed amperometric detection: The potential is still growing
journal, December 2000

Cataldi, T. R. I.; Campa, C.; De Benedetto, G. E.
Fresenius' Journal of Analytical Chemistry, Vol. 368, Issue 8
https://doi.org/10.1007/s002160000588

Grape Seed Extract Activates Th1 Cells In Vitro
journal, March 2002

Nair, N.; Mahajan, S.; Chawda, R.
Clinical and Vaccine Immunology, Vol. 9, Issue 2, p. 470-476
https://doi.org/10.1128/CDLI.9.2.470-476.2002

Antiviral property and mechanisms of a sulphated polysaccharide from the brown alga Sargassum patens against Herpes simplex virus type 1
journal, November 2006

Zhu, W.; Chiu, L. C. M.; Ooi, V. E. C.
Phytomedicine, Vol. 13, Issue 9-10, p. 695-701
https://doi.org/10.1016/j.phymed.2005.11.003

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Title: High molecular weight polysaccharide that binds and inhibits virus

Abstract

Citation Formats

Acidic polysaccharide CH-1 isolated from Chlorella pyrenoidosa and the use thereof patent, August 1985

Plant extract with a proanthocyanidins content as therapeutic agent having radical scavenger effect and use thereof patent, October 1987

Proanthocyanidin polymers having antiviral activity and methods of obtaining same patent, May 1993

Process for preparing grapeseed extracts enriched in procyanidol oligomers patent, January 1996

Antiviral polysaccharide patent, December 1996

Immunogenic polypeptides that mimic a surface polysaccharide antigen of a pathogenic microorganism, method for obtaining the same, and their use in vaccine compositions patent, March 2003

Modified polysaccharide adjuvant-protein antigen conjugates, the preparation thereof and the use thereof patent, June 2003

High molecular weight polysaccharide fraction from aloe vera with immunostimulatory activity patent-application, February 2004

Lipid-regulating agent and use thereof patent-application, December 2006

Carbohydrate analysis by high-performance anion-exchange chromatography with pulsed amperometric detection: The potential is still growing journal, December 2000

Grape Seed Extract Activates Th1 Cells In Vitro journal, March 2002

Antiviral property and mechanisms of a sulphated polysaccharide from the brown alga Sargassum patens against Herpes simplex virus type 1 journal, November 2006

Acidic polysaccharide CH-1 isolated from Chlorella pyrenoidosa and the use thereof
patent, August 1985

Plant extract with a proanthocyanidins content as therapeutic agent having radical scavenger effect and use thereof
patent, October 1987

Proanthocyanidin polymers having antiviral activity and methods of obtaining same
patent, May 1993

Process for preparing grapeseed extracts enriched in procyanidol oligomers
patent, January 1996

Antiviral polysaccharide
patent, December 1996

Immunogenic polypeptides that mimic a surface polysaccharide antigen of a pathogenic microorganism, method for obtaining the same, and their use in vaccine compositions
patent, March 2003

Modified polysaccharide adjuvant-protein antigen conjugates, the preparation thereof and the use thereof
patent, June 2003

High molecular weight polysaccharide fraction from aloe vera with immunostimulatory activity
patent-application, February 2004

Lipid-regulating agent and use thereof
patent-application, December 2006

Carbohydrate analysis by high-performance anion-exchange chromatography with pulsed amperometric detection: The potential is still growing
journal, December 2000

Grape Seed Extract Activates Th1 Cells In Vitro
journal, March 2002

Antiviral property and mechanisms of a sulphated polysaccharide from the brown alga Sargassum patens against Herpes simplex virus type 1
journal, November 2006