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Title: Genetically modified yeast species, and fermentation processes using genetically modified yeast

Abstract

Yeast cells are transformed with an exogenous xylose isomerase gene. Additional genetic modifications enhance the ability of the transformed cells to ferment xylose to ethanol or other desired fermentation products. Those modifications include deletion of non-specific aldose reductase gene(s), deletion of xylitol dehydrogenase gene(s) and/or overexpression of xylulokinase.

Inventors:
 [1];  [2];  [2];  [2];  [3];  [3];  [4];  [5];  [2]
  1. Kingsport, TN
  2. Helsinki, FI
  3. Maple Grove, MN
  4. Cottage Grove, MN
  5. St. Bonifacius, MN
Issue Date:
Research Org.:
Cargill Incorporated, Wayzata, MN, USA
Sponsoring Org.:
USDOE
OSTI Identifier:
1113979
Patent Number(s):
8,623,633
Application Number:
13/107,882
Assignee:
Cargill Incorporated (Wayzata, MN)
DOE Contract Number:  
FC07-021D14349
Resource Type:
Patent
Resource Relation:
Patent File Date: 2011 May 14
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Rajgarhia, Vineet, Koivuranta, Kari, Penttila, Merja, Ilmen, Marja, Suominen, Pirkko, Aristidou, Aristos, Miller, Christopher Kenneth, Olson, Stacey, and Ruohonen, Laura. Genetically modified yeast species, and fermentation processes using genetically modified yeast. United States: N. p., 2014. Web.
Rajgarhia, Vineet, Koivuranta, Kari, Penttila, Merja, Ilmen, Marja, Suominen, Pirkko, Aristidou, Aristos, Miller, Christopher Kenneth, Olson, Stacey, & Ruohonen, Laura. Genetically modified yeast species, and fermentation processes using genetically modified yeast. United States.
Rajgarhia, Vineet, Koivuranta, Kari, Penttila, Merja, Ilmen, Marja, Suominen, Pirkko, Aristidou, Aristos, Miller, Christopher Kenneth, Olson, Stacey, and Ruohonen, Laura. Tue . "Genetically modified yeast species, and fermentation processes using genetically modified yeast". United States. https://www.osti.gov/servlets/purl/1113979.
@article{osti_1113979,
title = {Genetically modified yeast species, and fermentation processes using genetically modified yeast},
author = {Rajgarhia, Vineet and Koivuranta, Kari and Penttila, Merja and Ilmen, Marja and Suominen, Pirkko and Aristidou, Aristos and Miller, Christopher Kenneth and Olson, Stacey and Ruohonen, Laura},
abstractNote = {Yeast cells are transformed with an exogenous xylose isomerase gene. Additional genetic modifications enhance the ability of the transformed cells to ferment xylose to ethanol or other desired fermentation products. Those modifications include deletion of non-specific aldose reductase gene(s), deletion of xylitol dehydrogenase gene(s) and/or overexpression of xylulokinase.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2014},
month = {1}
}

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Works referenced in this record:

Deletion of the GRE3 Aldose Reductase Gene and Its Influence on Xylose Metabolism in Recombinant Strains of Saccharomyces cerevisiae Expressing the xylA and XKS1 Genes
journal, December 2001


Yeast vectors for integration at the HO locus
journal, June 2001


High-level functional expression of a fungal xylose isomerase: the key to efficient ethanolic fermentation of xylose by ?
journal, October 2003


Minimal metabolic engineering of for efficient anaerobic xylose fermentation a proof of principle
journal, March 2004


Xylose isomerase activity influences xylose fermentation with recombinant Saccharomyces cerevisiae strains expressing mutated xylA from Thermus thermophilus
journal, April 2003


Amino Acid Substitutions in the Yeast Pichia Stipitis Xylitol Dehydrogenase Coenzyme-Binding Domain Affect the Coenzyme Specificity
journal, February 1995


Xylose metabolism in the anaerobic fungus Piromyces sp. strain E2 follows the bacterial pathway
journal, June 2003

  • Harhangi, Harry R.; Akhmanova, Anna S.; Emmens, Roul
  • Archives of Microbiology, Vol. 180, Issue 2
  • DOI: 10.1007/s00203-003-0565-0