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Title: Genetically modified yeast species, and fermentation processes using genetically modified yeast

Abstract

Yeast cells are transformed with an exogenous xylose isomerase gene. Additional genetic modifications enhance the ability of the transformed cells to ferment xylose to ethanol or other desired fermentation products. Those modifications include deletion of non-specific aldose reductase gene(s), deletion of xylitol dehydrogenase gene(s) and/or overexpression of xylulokinase.

Inventors:
 [1];  [2];  [2];  [2];  [3];  [3];  [4];  [5];  [2]
  1. Kingsport, TN
  2. Helsinki, FI
  3. Maple Grove, MN
  4. Cottage Grove, MN
  5. St. Bonifacius, MN
Issue Date:
Research Org.:
Cargill Incorporated, Wayzata, MN, USA
Sponsoring Org.:
USDOE
OSTI Identifier:
1113979
Patent Number(s):
8623633
Application Number:
13/107,882
Assignee:
Cargill Incorporated (Wayzata, MN)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
DOE Contract Number:  
FC07-021D14349
Resource Type:
Patent
Resource Relation:
Patent File Date: 2011 May 14
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Rajgarhia, Vineet, Koivuranta, Kari, Penttila, Merja, Ilmen, Marja, Suominen, Pirkko, Aristidou, Aristos, Miller, Christopher Kenneth, Olson, Stacey, and Ruohonen, Laura. Genetically modified yeast species, and fermentation processes using genetically modified yeast. United States: N. p., 2014. Web.
Rajgarhia, Vineet, Koivuranta, Kari, Penttila, Merja, Ilmen, Marja, Suominen, Pirkko, Aristidou, Aristos, Miller, Christopher Kenneth, Olson, Stacey, & Ruohonen, Laura. Genetically modified yeast species, and fermentation processes using genetically modified yeast. United States.
Rajgarhia, Vineet, Koivuranta, Kari, Penttila, Merja, Ilmen, Marja, Suominen, Pirkko, Aristidou, Aristos, Miller, Christopher Kenneth, Olson, Stacey, and Ruohonen, Laura. Tue . "Genetically modified yeast species, and fermentation processes using genetically modified yeast". United States. https://www.osti.gov/servlets/purl/1113979.
@article{osti_1113979,
title = {Genetically modified yeast species, and fermentation processes using genetically modified yeast},
author = {Rajgarhia, Vineet and Koivuranta, Kari and Penttila, Merja and Ilmen, Marja and Suominen, Pirkko and Aristidou, Aristos and Miller, Christopher Kenneth and Olson, Stacey and Ruohonen, Laura},
abstractNote = {Yeast cells are transformed with an exogenous xylose isomerase gene. Additional genetic modifications enhance the ability of the transformed cells to ferment xylose to ethanol or other desired fermentation products. Those modifications include deletion of non-specific aldose reductase gene(s), deletion of xylitol dehydrogenase gene(s) and/or overexpression of xylulokinase.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2014},
month = {1}
}

Works referenced in this record:

Xylose utilization by recombinant yeasts
patent, February 1999


Xylose isomerase with improved properties
patent, November 2002


Processes for preparing tertiary aminoalkylorganometallic compounds
patent, November 2002


Transformed eukaryotic cells that directly convert xylose to xylulose
patent, November 2009


Yeast vectors for integration at the HO locus
journal, June 2001


Minimal metabolic engineering of for efficient anaerobic xylose fermentation a proof of principle
journal, March 2004


Amino Acid Substitutions in the Yeast Pichia Stipitis Xylitol Dehydrogenase Coenzyme-Binding Domain Affect the Coenzyme Specificity
journal, February 1995


Xylose metabolism in the anaerobic fungus Piromyces sp. strain E2 follows the bacterial pathway
journal, June 2003