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Title: Catheter based mid-infrared reflectance and reflectance generated absorption spectroscopy

Abstract

A method of characterizing conditions in a tissue, by (a) providing a catheter that has a light source that emits light in selected wavenumbers within the range of mid-IR spectrum; (b) directing the light from the catheter to an area of tissue at a location inside a blood vessel of a subject; (c) collecting light reflected from the location and generating a reflectance spectra; and (d) comparing the reflectance spectra to a reference spectra of normal tissue, whereby a location having an increased number of absorbance peaks at said selected wavenumbers indicates a tissue inside the blood vessel containing a physiological marker for atherosclerosis.

Inventors:
Issue Date:
Research Org.:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1107628
Patent Number(s):
8571640
Application Number:
10/582,422
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Holman, Hoi-Ying N. Catheter based mid-infrared reflectance and reflectance generated absorption spectroscopy. United States: N. p., 2013. Web.
Holman, Hoi-Ying N. Catheter based mid-infrared reflectance and reflectance generated absorption spectroscopy. United States.
Holman, Hoi-Ying N. Tue . "Catheter based mid-infrared reflectance and reflectance generated absorption spectroscopy". United States. https://www.osti.gov/servlets/purl/1107628.
@article{osti_1107628,
title = {Catheter based mid-infrared reflectance and reflectance generated absorption spectroscopy},
author = {Holman, Hoi-Ying N},
abstractNote = {A method of characterizing conditions in a tissue, by (a) providing a catheter that has a light source that emits light in selected wavenumbers within the range of mid-IR spectrum; (b) directing the light from the catheter to an area of tissue at a location inside a blood vessel of a subject; (c) collecting light reflected from the location and generating a reflectance spectra; and (d) comparing the reflectance spectra to a reference spectra of normal tissue, whereby a location having an increased number of absorbance peaks at said selected wavenumbers indicates a tissue inside the blood vessel containing a physiological marker for atherosclerosis.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2013},
month = {10}
}

Works referenced in this record:

Systems and methods of molecular spectroscopy to provide for the diagnosis of tissue
patent, February 2004


Catheter for laser angiosurgery
patent, April 1990


Luminal diagnostics employing spectral analysis
patent, October 2000


Mid-infrared reflectivity of experimental atheromas
journal, January 2008


Multichannel gas analyzer and method of use
patent, March 1989


Near infrared diagnostic method and instrument
patent, March 1993