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Title: Detection of magnetic resonance signals using a magnetoresistive sensor

Abstract

A method and apparatus are described wherein a micro sample of a fluidic material may be assayed without sample contamination using NMR techniques, in combination with magnetoresistive sensors. The fluidic material to be assayed is first subject to pre-polarization, in one embodiment, by passage through a magnetic field. The magnetization of the fluidic material is then subject to an encoding process, in one embodiment an rf-induced inversion by passage through an adiabatic fast-passage module. Thereafter, the changes in magnetization are detected by a pair of solid-state magnetoresistive sensors arranged in gradiometer mode. Miniaturization is afforded by the close spacing of the various modules.

Inventors:
; ; ; ; ;
Issue Date:
Research Org.:
LBNL (Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States))
Sponsoring Org.:
USDOE
OSTI Identifier:
1107574
Patent Number(s):
8,547,095
Application Number:
12/753,306
Assignee:
The Regents of the University of California (Oakland, CA) LBNL
DOE Contract Number:  
AC03-76SF00098; AC02-05CH11231
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Budker, Dmitry, Pines, Alexander, Xu, Shoujun, Hilty, Christian, Ledbetter, Micah P, and Bouchard, Louis S. Detection of magnetic resonance signals using a magnetoresistive sensor. United States: N. p., 2013. Web.
Budker, Dmitry, Pines, Alexander, Xu, Shoujun, Hilty, Christian, Ledbetter, Micah P, & Bouchard, Louis S. Detection of magnetic resonance signals using a magnetoresistive sensor. United States.
Budker, Dmitry, Pines, Alexander, Xu, Shoujun, Hilty, Christian, Ledbetter, Micah P, and Bouchard, Louis S. Tue . "Detection of magnetic resonance signals using a magnetoresistive sensor". United States. https://www.osti.gov/servlets/purl/1107574.
@article{osti_1107574,
title = {Detection of magnetic resonance signals using a magnetoresistive sensor},
author = {Budker, Dmitry and Pines, Alexander and Xu, Shoujun and Hilty, Christian and Ledbetter, Micah P and Bouchard, Louis S},
abstractNote = {A method and apparatus are described wherein a micro sample of a fluidic material may be assayed without sample contamination using NMR techniques, in combination with magnetoresistive sensors. The fluidic material to be assayed is first subject to pre-polarization, in one embodiment, by passage through a magnetic field. The magnetization of the fluidic material is then subject to an encoding process, in one embodiment an rf-induced inversion by passage through an adiabatic fast-passage module. Thereafter, the changes in magnetization are detected by a pair of solid-state magnetoresistive sensors arranged in gradiometer mode. Miniaturization is afforded by the close spacing of the various modules.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2013},
month = {10}
}

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