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Title: Rotanone analogs: method of preparation and use

Abstract

The present invention provides rotenone analogs and methods of making and using them. Labeled with single photon and positron emitting isotopes, the rotenone analogs of the present invention are useful in, for example, clinical imaging applications as tracers to measure cardiac blood flow and detect regions of ischemia.

Inventors:
; ; ;
Issue Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1097268
Patent Number(s):
8551448
Application Number:
12/273,509
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
DOE Contract Number:  
AC03-76F00098
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

VanBrocklin, Henry F, O'Neil, James P, Gibbs, Andrew R, and Erathodiyil, Nandanan. Rotanone analogs: method of preparation and use. United States: N. p., 2013. Web.
VanBrocklin, Henry F, O'Neil, James P, Gibbs, Andrew R, & Erathodiyil, Nandanan. Rotanone analogs: method of preparation and use. United States.
VanBrocklin, Henry F, O'Neil, James P, Gibbs, Andrew R, and Erathodiyil, Nandanan. Tue . "Rotanone analogs: method of preparation and use". United States. https://www.osti.gov/servlets/purl/1097268.
@article{osti_1097268,
title = {Rotanone analogs: method of preparation and use},
author = {VanBrocklin, Henry F and O'Neil, James P and Gibbs, Andrew R and Erathodiyil, Nandanan},
abstractNote = {The present invention provides rotenone analogs and methods of making and using them. Labeled with single photon and positron emitting isotopes, the rotenone analogs of the present invention are useful in, for example, clinical imaging applications as tracers to measure cardiac blood flow and detect regions of ischemia.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2013},
month = {10}
}

Works referenced in this record:

Assay of [3H] Dihydrorotenone Binding to Complex I in Intact Human Platelets
journal, September 1995


Synthesis of (2-[11C]methoxy)rotenone, a marker of mitochondrial complex I activity
journal, January 1995


Biosynthesis of rotenone and amorphigenin. Study of the origins of isopropenyl-substituted dihydrofuran E-rings using isotopically labelled late precursors
journal, January 1992


[F-18]-Fluororotenoids: Evaluation of Potential Myocardial Imaging Agents in an Isolated, Perfused Rabbit Heart Model
journal, January 1994