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Title: Porous-wall hollow glass microspheres as carriers for biomolecules

Abstract

The present invention includes compositions of porous-wall hollow glass microspheres and one or more biomolecules, wherein the one or more biomolecules are positioned within a void location within the hollow glass microsphere, and the use of such compositions for the diagnostic and/or therapeutic delivery of biomolecules.

Inventors:
; ; ;
Issue Date:
Research Org.:
Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)
Sponsoring Org.:
USDOE
OSTI Identifier:
1093547
Patent Number(s):
8535725
Application Number:
13/349,792
Assignee:
Georgia Health Sciences University Research Institute, Inc. (Augusta, GA); Savannah River Nuclear Solutions, LLC (Aiken, SC)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
DOE Contract Number:  
AC09-08SR22470
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Li, Shuyi, Dynan, William S, Wicks, George, and Serkiz, Steven. Porous-wall hollow glass microspheres as carriers for biomolecules. United States: N. p., 2013. Web.
Li, Shuyi, Dynan, William S, Wicks, George, & Serkiz, Steven. Porous-wall hollow glass microspheres as carriers for biomolecules. United States.
Li, Shuyi, Dynan, William S, Wicks, George, and Serkiz, Steven. Tue . "Porous-wall hollow glass microspheres as carriers for biomolecules". United States. https://www.osti.gov/servlets/purl/1093547.
@article{osti_1093547,
title = {Porous-wall hollow glass microspheres as carriers for biomolecules},
author = {Li, Shuyi and Dynan, William S and Wicks, George and Serkiz, Steven},
abstractNote = {The present invention includes compositions of porous-wall hollow glass microspheres and one or more biomolecules, wherein the one or more biomolecules are positioned within a void location within the hollow glass microsphere, and the use of such compositions for the diagnostic and/or therapeutic delivery of biomolecules.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2013},
month = {9}
}

Works referenced in this record:

Agarose-Dextran Gels as Synthetic Analogs of Glomerular Basement Membrane: Water Permeability
journal, April 2002


Porous-wall hollow glass microspheres as novel potential nanocarriers for biomedical applications
journal, February 2010


Antisense oligonucleotides to the epidermal growth factor receptor
journal, January 1999


Hollow porous-wall glass microspheres for hydrogen storage
patent-application, March 2006


RNAi‐based therapeutics–current status, challenges and prospects
journal, June 2009


Calcium phosphate microcarriers and microspheres
patent, April 2001


Antisense oligonucleotide—induced inhibition of adrenocorticotropic hormone release from cultured human corticotrophs
journal, August 1999


Challenges to macromolecular drug delivery
journal, January 2007


Targeted drug delivery via folate receptors
journal, March 2008


Stability engineering of antibody single-chain Fv fragments
journal, February 2001


Non-coding RNAs: regulators of disease: Non-coding RNAs: regulators of disease
journal, October 2009


A universal strategy for stable intracellular antibodies
journal, August 2005


The Shape of Immunoglobulin G Molecules in Solution
journal, April 1972


Novel RNA-based Strategies for Therapeutic Gene Silencing
journal, March 2010


Small-interfering RNAs in the radar of the interferon system
journal, September 2003


RNAi mechanisms and applications
journal, April 2008


Mechanisms and strategies for effective delivery of antisense and siRNA oligonucleotides
journal, May 2008


Hollow porous-wall glass microspheres for hydrogen storage
patent, February 2010


Soluble receptors in human disease
journal, August 1998


E. coli expression of a soluble, active single-chain antibody variable fragment containing a nuclear localization signal
journal, August 2009