Facilitating protein solubility by use of peptide extensions
Abstract
Expression vectors for expression of a protein or polypeptide of interest as a fusion product composed of the protein or polypeptide of interest fused at one terminus to a solubility enhancing peptide extension are provided. Sequences encoding the peptide extensions are provided. The invention further comprises antibodies which bind specifically to one or more of the solubility enhancing peptide extensions.
- Inventors:
- Issue Date:
- Research Org.:
- Brookhaven National Laboratory (BNL), Upton, NY (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1093445
- Patent Number(s):
- 8535908
- Application Number:
- 12/684,195
- Assignee:
- Brookhaven Science Associates, LLC (Upton, NY)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
- DOE Contract Number:
- AC02-98CH10886
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Freimuth, Paul I, Zhang, Yian-Biao, and Howitt, Jason. Facilitating protein solubility by use of peptide extensions. United States: N. p., 2013.
Web.
Freimuth, Paul I, Zhang, Yian-Biao, & Howitt, Jason. Facilitating protein solubility by use of peptide extensions. United States.
Freimuth, Paul I, Zhang, Yian-Biao, and Howitt, Jason. Tue .
"Facilitating protein solubility by use of peptide extensions". United States. https://www.osti.gov/servlets/purl/1093445.
@article{osti_1093445,
title = {Facilitating protein solubility by use of peptide extensions},
author = {Freimuth, Paul I and Zhang, Yian-Biao and Howitt, Jason},
abstractNote = {Expression vectors for expression of a protein or polypeptide of interest as a fusion product composed of the protein or polypeptide of interest fused at one terminus to a solubility enhancing peptide extension are provided. Sequences encoding the peptide extensions are provided. The invention further comprises antibodies which bind specifically to one or more of the solubility enhancing peptide extensions.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Sep 17 00:00:00 EDT 2013},
month = {Tue Sep 17 00:00:00 EDT 2013}
}
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