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Title: Selective high-affinity polydentate ligands and methods of making such

Abstract

This invention provides polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each binds different regions on the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.

Inventors:
; ;
Issue Date:
Research Org.:
LLNL (Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States))
Sponsoring Org.:
USDOE
OSTI Identifier:
1093436
Patent Number(s):
8,536,133
Application Number:
12/642,684
Assignee:
Lawrence Livermore National Security, LLC. (Livermore, CA); The Regents of the University of California (Oakland, CA)
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

DeNardo, Sally, DeNardo, Gerald, and Balhorn, Rodney. Selective high-affinity polydentate ligands and methods of making such. United States: N. p., 2013. Web.
DeNardo, Sally, DeNardo, Gerald, & Balhorn, Rodney. Selective high-affinity polydentate ligands and methods of making such. United States.
DeNardo, Sally, DeNardo, Gerald, and Balhorn, Rodney. Tue . "Selective high-affinity polydentate ligands and methods of making such". United States. https://www.osti.gov/servlets/purl/1093436.
@article{osti_1093436,
title = {Selective high-affinity polydentate ligands and methods of making such},
author = {DeNardo, Sally and DeNardo, Gerald and Balhorn, Rodney},
abstractNote = {This invention provides polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each binds different regions on the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2013},
month = {9}
}

Patent:

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