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Title: Compositions and methods for cancer treatment using targeted carbon nanotubes

Abstract

The present invention is a method for detecting and destroying cancer tumors. The method is based on the concept of associating a linking protein or linking peptide such as, but not limited to, annexin V or other annexins to carbon nanotubes such as single-walled carbon nanotubes (SWNTs) to form a protein-CNT complex. Said linking protein or peptide can selectively bind to cancerous cells, especially tumor vasculature endothelial cells, rather than to healthy ones by binding to cancer-specific external receptors such as anionic phospholipids including phosphatidylserine expressed on the outer surfaces of cancer cells only. Irradiation of bound CNTs with one or more specific electromagnetic wavelengths is then used to detect and destroy those cells to which the CNTs are bound via the linking protein or peptide thereby destroying the tumor or cancer cells and preferably an immunostimulant is provided to the patient to enhance the immune response against antigens released from the tumor or cancer cells.

Inventors:
; ;
Issue Date:
Research Org.:
Univ. of Oklahoma, Norman, OK (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1093287
Patent Number(s):
8518870
Application Number:
12/618,553
Assignee:
The Board of Regents of the University of Oklahoma (Norman, OK)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61N - ELECTROTHERAPY
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
DOE Contract Number:  
FG02-06ER64239
Resource Type:
Patent
Resource Relation:
Patent File Date: 2009 Nov 13
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Harrison, Jr., Roger G., Resasco, Daniel E., and Neves, Luis Filipe Ferreira. Compositions and methods for cancer treatment using targeted carbon nanotubes. United States: N. p., 2013. Web.
Harrison, Jr., Roger G., Resasco, Daniel E., & Neves, Luis Filipe Ferreira. Compositions and methods for cancer treatment using targeted carbon nanotubes. United States.
Harrison, Jr., Roger G., Resasco, Daniel E., and Neves, Luis Filipe Ferreira. Tue . "Compositions and methods for cancer treatment using targeted carbon nanotubes". United States. https://www.osti.gov/servlets/purl/1093287.
@article{osti_1093287,
title = {Compositions and methods for cancer treatment using targeted carbon nanotubes},
author = {Harrison, Jr., Roger G. and Resasco, Daniel E. and Neves, Luis Filipe Ferreira},
abstractNote = {The present invention is a method for detecting and destroying cancer tumors. The method is based on the concept of associating a linking protein or linking peptide such as, but not limited to, annexin V or other annexins to carbon nanotubes such as single-walled carbon nanotubes (SWNTs) to form a protein-CNT complex. Said linking protein or peptide can selectively bind to cancerous cells, especially tumor vasculature endothelial cells, rather than to healthy ones by binding to cancer-specific external receptors such as anionic phospholipids including phosphatidylserine expressed on the outer surfaces of cancer cells only. Irradiation of bound CNTs with one or more specific electromagnetic wavelengths is then used to detect and destroy those cells to which the CNTs are bound via the linking protein or peptide thereby destroying the tumor or cancer cells and preferably an immunostimulant is provided to the patient to enhance the immune response against antigens released from the tumor or cancer cells.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2013},
month = {8}
}

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