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Title: Multidimensional bioseparation with modular microfluidics

Abstract

A multidimensional chemical separation and analysis system is described including a prototyping platform and modular microfluidic components capable of rapid and convenient assembly, alteration and disassembly of numerous candidate separation systems. Partial or total computer control of the separation system is possible. Single or multiple alternative processing trains can be tested, optimized and/or run in parallel. Examples related to the separation and analysis of human bodily fluids are given.

Inventors:
;
Issue Date:
Research Org.:
Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1093279
Patent Number(s):
8518346
Application Number:
12/157,601
Assignee:
Sandia Corporation (Albuquerque, NM)
Patent Classifications (CPCs):
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
DOE Contract Number:  
AC04-94AL85000
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Chirica, Gabriela S., and Renzi, Ronald F. Multidimensional bioseparation with modular microfluidics. United States: N. p., 2013. Web.
Chirica, Gabriela S., & Renzi, Ronald F. Multidimensional bioseparation with modular microfluidics. United States.
Chirica, Gabriela S., and Renzi, Ronald F. Tue . "Multidimensional bioseparation with modular microfluidics". United States. https://www.osti.gov/servlets/purl/1093279.
@article{osti_1093279,
title = {Multidimensional bioseparation with modular microfluidics},
author = {Chirica, Gabriela S. and Renzi, Ronald F.},
abstractNote = {A multidimensional chemical separation and analysis system is described including a prototyping platform and modular microfluidic components capable of rapid and convenient assembly, alteration and disassembly of numerous candidate separation systems. Partial or total computer control of the separation system is possible. Single or multiple alternative processing trains can be tested, optimized and/or run in parallel. Examples related to the separation and analysis of human bodily fluids are given.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2013},
month = {8}
}

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Scalable continuous production system
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Apparatus and method for concurrent chemical synthesis
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Microliter scale solid phase extraction devices
patent-application, July 2006


Microfluidics Prototyping Platform and Components
patent-application, August 2006


A List of Candidate Cancer Biomarkers for Targeted Proteomics
journal, January 2006


Computational prediction of proteotypic peptides for quantitative proteomics
journal, December 2006


Concepts and comparisons in multidimensional separation
journal, May 1987