DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Methods for attaching polymerizable ceragenins to water treatment membranes using silane linkages

Abstract

This invention relates to methods for chemically grafting and attaching ceragenin molecules to polymer substrates; methods for synthesizing ceragenin-containing copolymers; methods for making ceragenin-modified water treatment membranes and spacers; and methods of treating contaminated water using ceragenin-modified treatment membranes and spacers. Ceragenins are synthetically produced antimicrobial peptide mimics that display broad-spectrum bactericidal activity. Alkene-functionalized ceragenins (e.g., acrylamide-functionalized ceragenins) can be attached to polyamide reverse osmosis membranes using amine-linking, amide-linking, UV-grafting, or silane-coating methods. In addition, silane-functionalized ceragenins can be directly attached to polymer surfaces that have free hydroxyls.

Inventors:
; ; ;
Issue Date:
Research Org.:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1092937
Patent Number(s):
8530002
Application Number:
12/986,221
Assignee:
Sandia Corporation (Albuquerque, NM)
Patent Classifications (CPCs):
C - CHEMISTRY C08 - ORGANIC MACROMOLECULAR COMPOUNDS C08F - MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
C - CHEMISTRY C09 - DYES C09D - COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS
DOE Contract Number:  
AC04-94AL85000
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Hibbs, Michael, Altman, Susan J., Jones, Howland D. T., and Savage, Paul B. Methods for attaching polymerizable ceragenins to water treatment membranes using silane linkages. United States: N. p., 2013. Web.
Hibbs, Michael, Altman, Susan J., Jones, Howland D. T., & Savage, Paul B. Methods for attaching polymerizable ceragenins to water treatment membranes using silane linkages. United States.
Hibbs, Michael, Altman, Susan J., Jones, Howland D. T., and Savage, Paul B. Tue . "Methods for attaching polymerizable ceragenins to water treatment membranes using silane linkages". United States. https://www.osti.gov/servlets/purl/1092937.
@article{osti_1092937,
title = {Methods for attaching polymerizable ceragenins to water treatment membranes using silane linkages},
author = {Hibbs, Michael and Altman, Susan J. and Jones, Howland D. T. and Savage, Paul B.},
abstractNote = {This invention relates to methods for chemically grafting and attaching ceragenin molecules to polymer substrates; methods for synthesizing ceragenin-containing copolymers; methods for making ceragenin-modified water treatment membranes and spacers; and methods of treating contaminated water using ceragenin-modified treatment membranes and spacers. Ceragenins are synthetically produced antimicrobial peptide mimics that display broad-spectrum bactericidal activity. Alkene-functionalized ceragenins (e.g., acrylamide-functionalized ceragenins) can be attached to polyamide reverse osmosis membranes using amine-linking, amide-linking, UV-grafting, or silane-coating methods. In addition, silane-functionalized ceragenins can be directly attached to polymer surfaces that have free hydroxyls.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2013},
month = {9}
}

Works referenced in this record:

Selective membrane having a high fouling resistance
patent, May 2009


Promoting the cytocompatibility of polyurethane scaffolds via surface photo-grafting polymerization of acrylamide
journal, March 2004


Steroid derived antibiotics
patent, July 2004


Cationic steroid antimicrobial compositions and methods of use
patent, July 2010


Functionalized substrates
patent, June 2009


Process for improving membranes
patent, March 2010


Peptide Antimicrobial Agents
journal, July 2006


Selective membrane having a high fouling resistance
patent, July 2005


Cationic Steroid Antibiotics
journal, July 2002