Methods for attaching polymerizable ceragenins to water treatment membranes using silane linkages
Abstract
This invention relates to methods for chemically grafting and attaching ceragenin molecules to polymer substrates; methods for synthesizing ceragenin-containing copolymers; methods for making ceragenin-modified water treatment membranes and spacers; and methods of treating contaminated water using ceragenin-modified treatment membranes and spacers. Ceragenins are synthetically produced antimicrobial peptide mimics that display broad-spectrum bactericidal activity. Alkene-functionalized ceragenins (e.g., acrylamide-functionalized ceragenins) can be attached to polyamide reverse osmosis membranes using amine-linking, amide-linking, UV-grafting, or silane-coating methods. In addition, silane-functionalized ceragenins can be directly attached to polymer surfaces that have free hydroxyls.
- Inventors:
- Issue Date:
- Research Org.:
- Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1092937
- Patent Number(s):
- 8530002
- Application Number:
- 12/986,221
- Assignee:
- Sandia Corporation (Albuquerque, NM)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C09 - DYES C09D - COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS
C - CHEMISTRY C08 - ORGANIC MACROMOLECULAR COMPOUNDS C08F - MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- DOE Contract Number:
- AC04-94AL85000
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Citation Formats
Hibbs, Michael, Altman, Susan J., Jones, Howland D. T., and Savage, Paul B. Methods for attaching polymerizable ceragenins to water treatment membranes using silane linkages. United States: N. p., 2013.
Web.
Hibbs, Michael, Altman, Susan J., Jones, Howland D. T., & Savage, Paul B. Methods for attaching polymerizable ceragenins to water treatment membranes using silane linkages. United States.
Hibbs, Michael, Altman, Susan J., Jones, Howland D. T., and Savage, Paul B. Tue .
"Methods for attaching polymerizable ceragenins to water treatment membranes using silane linkages". United States. https://www.osti.gov/servlets/purl/1092937.
@article{osti_1092937,
title = {Methods for attaching polymerizable ceragenins to water treatment membranes using silane linkages},
author = {Hibbs, Michael and Altman, Susan J. and Jones, Howland D. T. and Savage, Paul B.},
abstractNote = {This invention relates to methods for chemically grafting and attaching ceragenin molecules to polymer substrates; methods for synthesizing ceragenin-containing copolymers; methods for making ceragenin-modified water treatment membranes and spacers; and methods of treating contaminated water using ceragenin-modified treatment membranes and spacers. Ceragenins are synthetically produced antimicrobial peptide mimics that display broad-spectrum bactericidal activity. Alkene-functionalized ceragenins (e.g., acrylamide-functionalized ceragenins) can be attached to polyamide reverse osmosis membranes using amine-linking, amide-linking, UV-grafting, or silane-coating methods. In addition, silane-functionalized ceragenins can be directly attached to polymer surfaces that have free hydroxyls.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2013},
month = {9}
}
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