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Title: Biofouling-resistant ceragenin-modified materials and structures for water treatment

Abstract

This invention relates to methods for chemically grafting and attaching ceragenin molecules to polymer substrates; methods for synthesizing ceragenin-containing copolymers; methods for making ceragenin-modified water treatment membranes and spacers; and methods of treating contaminated water using ceragenin-modified treatment membranes and spacers. Ceragenins are synthetically produced antimicrobial peptide mimics that display broad-spectrum bactericidal activity. Alkene-functionalized ceragenins (e.g., acrylamide-functionalized ceragenins) can be attached to polyamide reverse osmosis membranes using amine-linking, amide-linking, UV-grafting, or silane-coating methods. In addition, silane-functionalized ceragenins can be directly attached to polymer surfaces that have free hydroxyls.

Inventors:
; ; ;
Issue Date:
Research Org.:
SNL-A (Sandia National Laboratories, Albuquerque, NM (United States))
Sponsoring Org.:
USDOE
OSTI Identifier:
1092910
Patent Number(s):
8,529,681
Application Number:
12/986,234
Assignee:
Sandia Corporation (Albuquerque, NM)
DOE Contract Number:  
AC04-94AL85000
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE

Citation Formats

Hibbs, Michael, Altman, Susan J., Jones, Howland D. T., and Savage, Paul B. Biofouling-resistant ceragenin-modified materials and structures for water treatment. United States: N. p., 2013. Web.
Hibbs, Michael, Altman, Susan J., Jones, Howland D. T., & Savage, Paul B. Biofouling-resistant ceragenin-modified materials and structures for water treatment. United States.
Hibbs, Michael, Altman, Susan J., Jones, Howland D. T., and Savage, Paul B. Tue . "Biofouling-resistant ceragenin-modified materials and structures for water treatment". United States. https://www.osti.gov/servlets/purl/1092910.
@article{osti_1092910,
title = {Biofouling-resistant ceragenin-modified materials and structures for water treatment},
author = {Hibbs, Michael and Altman, Susan J. and Jones, Howland D. T. and Savage, Paul B.},
abstractNote = {This invention relates to methods for chemically grafting and attaching ceragenin molecules to polymer substrates; methods for synthesizing ceragenin-containing copolymers; methods for making ceragenin-modified water treatment membranes and spacers; and methods of treating contaminated water using ceragenin-modified treatment membranes and spacers. Ceragenins are synthetically produced antimicrobial peptide mimics that display broad-spectrum bactericidal activity. Alkene-functionalized ceragenins (e.g., acrylamide-functionalized ceragenins) can be attached to polyamide reverse osmosis membranes using amine-linking, amide-linking, UV-grafting, or silane-coating methods. In addition, silane-functionalized ceragenins can be directly attached to polymer surfaces that have free hydroxyls.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2013},
month = {9}
}

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