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Title: Methods and compositions for targeting macromolecules into the nucleus

Abstract

The present invention includes compositions, methods and kits for directing an agent across the nuclear membrane of a cell. The present invention includes a Karyopherin beta2 translocation motif in a polypeptide having a slightly positively charged region or a slightly hydrophobic region and one or more R/K/H-X.sub.(2-5)-P-Y motifs. The polypeptide targets the agent into the cell nucleus.

Inventors:
Issue Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1086949
Patent Number(s):
8470976
Application Number:
11/697,656
Assignee:
Board of Regents, The University of Texas System (Austin, TX)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
DOE Contract Number:  
W-31-109-ENG-38
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Chook, Yuh Min. Methods and compositions for targeting macromolecules into the nucleus. United States: N. p., 2013. Web.
Chook, Yuh Min. Methods and compositions for targeting macromolecules into the nucleus. United States.
Chook, Yuh Min. Tue . "Methods and compositions for targeting macromolecules into the nucleus". United States. https://www.osti.gov/servlets/purl/1086949.
@article{osti_1086949,
title = {Methods and compositions for targeting macromolecules into the nucleus},
author = {Chook, Yuh Min},
abstractNote = {The present invention includes compositions, methods and kits for directing an agent across the nuclear membrane of a cell. The present invention includes a Karyopherin beta2 translocation motif in a polypeptide having a slightly positively charged region or a slightly hydrophobic region and one or more R/K/H-X.sub.(2-5)-P-Y motifs. The polypeptide targets the agent into the cell nucleus.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2013},
month = {6}
}

Works referenced in this record:

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