Methods and compositions for targeting macromolecules into the nucleus
Abstract
The present invention includes compositions, methods and kits for directing an agent across the nuclear membrane of a cell. The present invention includes a Karyopherin beta2 translocation motif in a polypeptide having a slightly positively charged region or a slightly hydrophobic region and one or more R/K/H-X.sub.(2-5)-P-Y motifs. The polypeptide targets the agent into the cell nucleus.
- Inventors:
- Issue Date:
- Research Org.:
- Argonne National Lab. (ANL), Argonne, IL (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1086949
- Patent Number(s):
- 8470976
- Application Number:
- 11/697,656
- Assignee:
- Board of Regents, The University of Texas System (Austin, TX)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- DOE Contract Number:
- W-31-109-ENG-38
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Chook, Yuh Min. Methods and compositions for targeting macromolecules into the nucleus. United States: N. p., 2013.
Web.
Chook, Yuh Min. Methods and compositions for targeting macromolecules into the nucleus. United States.
Chook, Yuh Min. Tue .
"Methods and compositions for targeting macromolecules into the nucleus". United States. https://www.osti.gov/servlets/purl/1086949.
@article{osti_1086949,
title = {Methods and compositions for targeting macromolecules into the nucleus},
author = {Chook, Yuh Min},
abstractNote = {The present invention includes compositions, methods and kits for directing an agent across the nuclear membrane of a cell. The present invention includes a Karyopherin beta2 translocation motif in a polypeptide having a slightly positively charged region or a slightly hydrophobic region and one or more R/K/H-X.sub.(2-5)-P-Y motifs. The polypeptide targets the agent into the cell nucleus.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2013},
month = {6}
}
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