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Title: Probe and method for DNA detection

Abstract

A hybridization probe containing two linear strands of DNA lights up upon hybridization to a target DNA using silver nanoclusters that have been templated onto one of the DNA strands. Hybridization induces proximity between the nanoclusters on one strand and an overhang on the other strand, which results in enhanced fluorescence emission from the nanoclusters.

Inventors:
; ; ;
Issue Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1086746
Patent Number(s):
8476014
Application Number:
12/932,321
Assignee:
Los Alamos National Security, LLC (Los Alamos, NM)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
DOE Contract Number:  
AC52-06NA25396
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Yeh, Hsin-Chih, Werner, James Henry, Sharma, Jaswinder Kumar, and Martinez, Jennifer Suzanne. Probe and method for DNA detection. United States: N. p., 2013. Web.
Yeh, Hsin-Chih, Werner, James Henry, Sharma, Jaswinder Kumar, & Martinez, Jennifer Suzanne. Probe and method for DNA detection. United States.
Yeh, Hsin-Chih, Werner, James Henry, Sharma, Jaswinder Kumar, and Martinez, Jennifer Suzanne. Tue . "Probe and method for DNA detection". United States. https://www.osti.gov/servlets/purl/1086746.
@article{osti_1086746,
title = {Probe and method for DNA detection},
author = {Yeh, Hsin-Chih and Werner, James Henry and Sharma, Jaswinder Kumar and Martinez, Jennifer Suzanne},
abstractNote = {A hybridization probe containing two linear strands of DNA lights up upon hybridization to a target DNA using silver nanoclusters that have been templated onto one of the DNA strands. Hybridization induces proximity between the nanoclusters on one strand and an overhang on the other strand, which results in enhanced fluorescence emission from the nanoclusters.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2013},
month = {7}
}

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