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Title: Materials and methods for stabilizing nanoparticles in salt solutions

Abstract

Sequence-specific polymers are proving to be a powerful approach to assembly and manipulation of matter on the nanometer scale. Ligands that are peptoids, or sequence-specific N-functional glycine oligomers, allow precise and flexible control over the arrangement of binding groups, steric spacers, charge, and other functionality. We have synthesized short peptoids that can prevent the aggregation of gold nanoparticles in high-salt environments including divalent salt, and allow co-adsorption of a single DNA molecule. This degree of precision and versatility is likely to prove essential in bottom-up assembly of nanostructures and in biomedical applications of nanomaterials.

Inventors:
; ;
Issue Date:
Research Org.:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1084247
Patent Number(s):
8461300
Application Number:
13/005,250
Assignee:
Sandia Corporation (Albuquerque, NM)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
DOE Contract Number:  
AC04-94AL85000
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE

Citation Formats

Robinson, David Bruce, Zuckermann, Ronald, and Buffleben, George M. Materials and methods for stabilizing nanoparticles in salt solutions. United States: N. p., 2013. Web.
Robinson, David Bruce, Zuckermann, Ronald, & Buffleben, George M. Materials and methods for stabilizing nanoparticles in salt solutions. United States.
Robinson, David Bruce, Zuckermann, Ronald, and Buffleben, George M. Tue . "Materials and methods for stabilizing nanoparticles in salt solutions". United States. https://www.osti.gov/servlets/purl/1084247.
@article{osti_1084247,
title = {Materials and methods for stabilizing nanoparticles in salt solutions},
author = {Robinson, David Bruce and Zuckermann, Ronald and Buffleben, George M.},
abstractNote = {Sequence-specific polymers are proving to be a powerful approach to assembly and manipulation of matter on the nanometer scale. Ligands that are peptoids, or sequence-specific N-functional glycine oligomers, allow precise and flexible control over the arrangement of binding groups, steric spacers, charge, and other functionality. We have synthesized short peptoids that can prevent the aggregation of gold nanoparticles in high-salt environments including divalent salt, and allow co-adsorption of a single DNA molecule. This degree of precision and versatility is likely to prove essential in bottom-up assembly of nanostructures and in biomedical applications of nanomaterials.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2013},
month = {6}
}

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