System and process for pulsed multiple reaction monitoring
Abstract
A new pulsed multiple reaction monitoring process and system are disclosed that uses a pulsed ion injection mode for use in conjunction with triple-quadrupole instruments. The pulsed injection mode approach reduces background ion noise at the detector, increases amplitude of the ion signal, and includes a unity duty cycle that provides a significant sensitivity increase for reliable quantitation of proteins/peptides present at attomole levels in highly complex biological mixtures.
- Inventors:
- Issue Date:
- Research Org.:
- Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1084053
- Patent Number(s):
- 8440963
- Application Number:
- 12/871,685
- Assignee:
- Battelle Memorial Institute (Richland, WA)
- Patent Classifications (CPCs):
-
H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- DOE Contract Number:
- AC05-76RLO5640
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 47 OTHER INSTRUMENTATION
Citation Formats
Belov, Mikhail E. System and process for pulsed multiple reaction monitoring. United States: N. p., 2013.
Web.
Belov, Mikhail E. System and process for pulsed multiple reaction monitoring. United States.
Belov, Mikhail E. Fri .
"System and process for pulsed multiple reaction monitoring". United States. https://www.osti.gov/servlets/purl/1084053.
@article{osti_1084053,
title = {System and process for pulsed multiple reaction monitoring},
author = {Belov, Mikhail E},
abstractNote = {A new pulsed multiple reaction monitoring process and system are disclosed that uses a pulsed ion injection mode for use in conjunction with triple-quadrupole instruments. The pulsed injection mode approach reduces background ion noise at the detector, increases amplitude of the ion signal, and includes a unity duty cycle that provides a significant sensitivity increase for reliable quantitation of proteins/peptides present at attomole levels in highly complex biological mixtures.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Fri May 17 00:00:00 EDT 2013},
month = {Fri May 17 00:00:00 EDT 2013}
}
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