DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Symmetric and asymmetric halogen-containing metallocarboranylporphyrins and uses thereof

Abstract

The present invention is directed to low toxicity boronated compounds and methods for their use in the treatment, visualization, and diagnosis of tumors. More specifically, the present invention is directed to low toxicity halogenated, carborane-containing 5,10,15,20-tetraphenylporphyrin compounds and methods for their use particularly in boron neutron capture therapy (BNCT) and photodynamic therapy (PDT) for the treatment of tumors of the brain, head and neck, and surrounding tissue. The invention is also directed to using these halogenated, carborane-containing tetraphenylporphyrin compounds in methods of tumor imaging and/or diagnosis such as MRI, SPECT, or PET.

Inventors:
;
Issue Date:
Research Org.:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1084033
Patent Number(s):
8444953
Application Number:
11/689,678
Assignee:
Brookhaven Science Associates, LLC (Upton, NY)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
DOE Contract Number:  
AC02-98CH10886
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Miura, Michiko, and Wu, Haitao. Symmetric and asymmetric halogen-containing metallocarboranylporphyrins and uses thereof. United States: N. p., 2013. Web.
Miura, Michiko, & Wu, Haitao. Symmetric and asymmetric halogen-containing metallocarboranylporphyrins and uses thereof. United States.
Miura, Michiko, and Wu, Haitao. Tue . "Symmetric and asymmetric halogen-containing metallocarboranylporphyrins and uses thereof". United States. https://www.osti.gov/servlets/purl/1084033.
@article{osti_1084033,
title = {Symmetric and asymmetric halogen-containing metallocarboranylporphyrins and uses thereof},
author = {Miura, Michiko and Wu, Haitao},
abstractNote = {The present invention is directed to low toxicity boronated compounds and methods for their use in the treatment, visualization, and diagnosis of tumors. More specifically, the present invention is directed to low toxicity halogenated, carborane-containing 5,10,15,20-tetraphenylporphyrin compounds and methods for their use particularly in boron neutron capture therapy (BNCT) and photodynamic therapy (PDT) for the treatment of tumors of the brain, head and neck, and surrounding tissue. The invention is also directed to using these halogenated, carborane-containing tetraphenylporphyrin compounds in methods of tumor imaging and/or diagnosis such as MRI, SPECT, or PET.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2013},
month = {5}
}

Works referenced in this record:

The Effect of Macromolecular Architecture in Nanomaterials:  A Comparison of Site Isolation in Porphyrin Core Dendrimers and Their Isomeric Linear Analogues
journal, April 2002


Synthesis of carboranyl derivatives of deuteroporphyrin IX
journal, December 1999


In vivo animal studies with gadolinium (III) texaphyrin as a radiation enhancer
journal, November 1999


Galectin recognized photosensitizers for photodynamic therapy
patent, February 2005


Carboranylporphyrins and uses Thereof
patent-application, November 2005


The solubilities of tetra(monofluorophenyl) porphines
journal, November 1973


Porphyrins for boron neutron capture therapy
patent, September 1990


Boron dipeptide compounds
patent, December 1990


A Straightforward Synthesis of 3,4-Difluoropyrrole
journal, August 1998


Porphyrin-mediated boron neutron capture therapy: evaluation of the reactions of skin and central nervous system
journal, January 2003


Methods for cancer chemosensitization
patent, July 1998


Rapid synthesis of radiolabeled porphyrin complexes for medical application
patent, November 1988


Synthesis of new glycosylated neutral and cationic porphyrins dimers
journal, January 2000


Ion conducting electrolyte material containing a lithium porphyrin complex
patent, January 2000


Regioisomerically pure oxochlorins and methods of synthesis
patent, July 2004


Synthesis and biological evaluation of thioglycosylated porphyrins for an application in photodynamic therapy
journal, January 2002


Carboranyl uridines and their use in boron neutron capture therapy
patent, November 1995


A Carboranyl Porphyrin for Boron Neutron Capture Therapy of Brain Tumors
book, January 1989


Synthesis and investigation of glycosylated mono- and diarylporphyrins for photodynamic therapy
journal, September 1999


Method of using 5,10,15,20-tetrakis(carboxyphenyl)porphine for detecting cancers of the lung
patent, November 1992


Neutron capture therapy of the 9l rat gliosarcoma using the P-boronophenylalanine-fructose complex
journal, October 1994


Carboranylporphyrins and uses thereof
patent, January 2006


Carborane Complexes of Nickel and Platinum: Synthesis and Protonation Reactions of Anionic Allyl(carborane) Species
journal, April 1994


Accumulation of Boron in Malignant and Normal Cells Incubated In Vitro with Boronophenylalanine, Mercaptoborane or Boric Acid
journal, November 1996


Treatment of urogenital cancer with boron neutron capture therapy
patent, February 1997


Synthesis of a porphyrin-labelled carboranyl phosphate diester: a potential new drug for boron neutron capture therapy of cancer
journal, July 2002


Highly boronated derivatives of texaphyrins
patent, September 1999


Biodistribution and toxicity of 2,4-divinyl-nido-o-carboranyldeuteroporphyrin IX in mice
journal, February 1992


Synthesis, dark toxicity and induction of in vitro DNA photodamage by a tetra(4-nido-carboranylphenyl)porphyrin
journal, November 2002


19F NMR Spectra and Structures of Halogenated Porphyrins
journal, July 1995


Porphyrin Based neuton capture agents for cancer therapy
patent, June 2006


Metal ion porphyrin-containing poly(imide)
patent, May 1994


Boronated porphyrin compounds
patent, September 1992


Synthesis of 5-(4-Acetamidophenyl)-10,15,20- tris (4-Substituted Phenyl) Porphyrins using Dipyrromethanes
journal, October 1999


Glycoconjugated porphyrins. 2. Synthesis of sterically constrained polyglycosylated compounds derived from tetraphenylporphyrins
journal, May 1993


Non-iron metalloporphyrins and methods of use
patent, May 2000


Porphyrins
patent, January 1990


Evaluation of carborane-containing porphyrins as tumour targeting agents for boron neutron capture therapy.
journal, July 1998


Syntheses of carboncarbon linked carboranylated porphyrins for boron neutron capture therapy of cancer
journal, September 2000


Biodistribution of Copper Carboranyltetraphenylporphyrins in Rodents Bearing an Isogeneic or Human Neoplasm
journal, January 2001


Membrane incorporation of texaphyrins
patent, April 2002


Boronated metalloporphyrine and therapeutic methods
patent, August 1997


Boron neutron capture therapy for glioblastoma multiforme using p-boronophenylalanine and epithermal neutrons: Trial design and early clinical results
journal, May 1997


Antibody conjugates
patent, April 1989


Two-step cancer treatment method
patent, October 1996


Carboranylporphyrins and uses thereof
patent, February 2006


Boronated porhyrins and methods for their use
patent, March 1999


Tetraphenylbacteriochlorin derivatives and compositions containing the same
patent, October 2005


Synthesis of New Glycosylated Porphyrin Derivatives with a Hydrocarbon Spacer Arm
journal, January 1993