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Title: Anti-cancer agents based on N-acyl-2, 3-dihydro-1H-pyrrolo[2,3-b] quinoline derivatives and a method of making

Abstract

The present disclosure relates to novel compounds that can be used as anti-cancer agents in the prostate cancer therapy. In particular, the invention relates to N-acyl derivatives of 2,3-dihydro-1H-pyrrolo[2,3-b]quinolines having the structural Formula (I), ##STR00001## stereoisomers, tautomers, racemics, prodrugs, metabolites thereof, or pharmaceutically acceptable salt and/or solvate thereof. The meaning of R1 is independently selected from H; C1-C6 Alkyl, cyclo-Alkyl or iso-Alkyl substituents; R2 is selected from C1-C6 Alkyl, cyclo-Alkyl or iso-Alkyl; substituted or non-substituted, fused or non-fused to substituted or non-substituted aromatic ring, aryl or heteroaryl groups. The invention also relates to methods for preparing said compounds, and to pharmaceutical compositions comprising said compounds.

Inventors:
; ; ; ; ; ; ;
Issue Date:
Research Org.:
US Department of Energy (USDOE), Washington DC (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1083454
Patent Number(s):
8420815
Application Number:
12/822,237
Assignee:
U.S. Department of Energy (Washington, DC)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Gakh, Andrei, Krasavin, Mikhail, Karapetian, Ruben, Rufanov, Konstantin A, Konstantinov, Igor, Godovykh, Elena, Soldatkina, Olga, and Sosnov, Andrey V. Anti-cancer agents based on N-acyl-2, 3-dihydro-1H-pyrrolo[2,3-b] quinoline derivatives and a method of making. United States: N. p., 2013. Web.
Gakh, Andrei, Krasavin, Mikhail, Karapetian, Ruben, Rufanov, Konstantin A, Konstantinov, Igor, Godovykh, Elena, Soldatkina, Olga, & Sosnov, Andrey V. Anti-cancer agents based on N-acyl-2, 3-dihydro-1H-pyrrolo[2,3-b] quinoline derivatives and a method of making. United States.
Gakh, Andrei, Krasavin, Mikhail, Karapetian, Ruben, Rufanov, Konstantin A, Konstantinov, Igor, Godovykh, Elena, Soldatkina, Olga, and Sosnov, Andrey V. Tue . "Anti-cancer agents based on N-acyl-2, 3-dihydro-1H-pyrrolo[2,3-b] quinoline derivatives and a method of making". United States. https://www.osti.gov/servlets/purl/1083454.
@article{osti_1083454,
title = {Anti-cancer agents based on N-acyl-2, 3-dihydro-1H-pyrrolo[2,3-b] quinoline derivatives and a method of making},
author = {Gakh, Andrei and Krasavin, Mikhail and Karapetian, Ruben and Rufanov, Konstantin A and Konstantinov, Igor and Godovykh, Elena and Soldatkina, Olga and Sosnov, Andrey V},
abstractNote = {The present disclosure relates to novel compounds that can be used as anti-cancer agents in the prostate cancer therapy. In particular, the invention relates to N-acyl derivatives of 2,3-dihydro-1H-pyrrolo[2,3-b]quinolines having the structural Formula (I), ##STR00001## stereoisomers, tautomers, racemics, prodrugs, metabolites thereof, or pharmaceutically acceptable salt and/or solvate thereof. The meaning of R1 is independently selected from H; C1-C6 Alkyl, cyclo-Alkyl or iso-Alkyl substituents; R2 is selected from C1-C6 Alkyl, cyclo-Alkyl or iso-Alkyl; substituted or non-substituted, fused or non-fused to substituted or non-substituted aromatic ring, aryl or heteroaryl groups. The invention also relates to methods for preparing said compounds, and to pharmaceutical compositions comprising said compounds.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2013},
month = {4}
}

Works referenced in this record:

Synthesis and cytotoxic activity of substituted Luotonin A derivatives
journal, December 2004