Producing biofuels using polyketide synthases
Abstract
The present invention provides for a non-naturally occurring polyketide synthase (PKS) capable of synthesizing a carboxylic acid or a lactone, and a composition such that a carboxylic acid or lactone is included. The carboxylic acid or lactone, or derivative thereof, is useful as a biofuel. The present invention also provides for a recombinant nucleic acid or vector that encodes such a PKS, and host cells which also have such a recombinant nucleic acid or vector. The present invention also provides for a method of producing such carboxylic acids or lactones using such a PKS.
- Inventors:
- Issue Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1083451
- Patent Number(s):
- 8420833
- Application Number:
- 12/921,463
- Assignee:
- The Regents of the University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y02 - TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE Y02E - REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- DOE Contract Number:
- AC02-05CH11231
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 09 BIOMASS FUELS
Citation Formats
Katz, Leonard, Fortman, Jeffrey L, and Keasling, Jay D. Producing biofuels using polyketide synthases. United States: N. p., 2013.
Web.
Katz, Leonard, Fortman, Jeffrey L, & Keasling, Jay D. Producing biofuels using polyketide synthases. United States.
Katz, Leonard, Fortman, Jeffrey L, and Keasling, Jay D. Tue .
"Producing biofuels using polyketide synthases". United States. https://www.osti.gov/servlets/purl/1083451.
@article{osti_1083451,
title = {Producing biofuels using polyketide synthases},
author = {Katz, Leonard and Fortman, Jeffrey L and Keasling, Jay D},
abstractNote = {The present invention provides for a non-naturally occurring polyketide synthase (PKS) capable of synthesizing a carboxylic acid or a lactone, and a composition such that a carboxylic acid or lactone is included. The carboxylic acid or lactone, or derivative thereof, is useful as a biofuel. The present invention also provides for a recombinant nucleic acid or vector that encodes such a PKS, and host cells which also have such a recombinant nucleic acid or vector. The present invention also provides for a method of producing such carboxylic acids or lactones using such a PKS.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Apr 16 00:00:00 EDT 2013},
month = {Tue Apr 16 00:00:00 EDT 2013}
}
Works referenced in this record:
A new synthesis of (±)-phoracantholide, (±)-dihydrorecifeiolide, and (±)-muscone via α-nitro ketones
journal, July 1995
- Ballini, Roberto; Marcantoni, Enrico; Petrini, Marino
- Liebigs Annalen, Vol. 1995, Issue 7
Role of type II thioesterases: evidence for removal of short acyl chains produced by aberrant decarboxylation of chain extender units
journal, February 2001
- Heathcote, Michelle L.; Staunton, James; Leadlay, Peter F.
- Chemistry & Biology, Vol. 8, Issue 2, p. 207-220
Recombinant production of novel polyketides
patent, September 1997
- Khosla, Chaitan; Hopwood, David A.; Ebert-Khosla, Suzanne
- US Patent Document 5,672,491
Recombinant combinatorial genetic library for the production of novel polyketides
patent, January 1998
- Khosla, Chaitan; Hopwood, David A.; Ebert-Khosla, Suzanne
- US Patent Document 5,712,146
Switching from S - to R- Selectivity in the Candida antarctica Lipase B-Catalyzed Ring-Opening of ω-Methylated Lactones: Tuning Polymerizations by Ring Size
journal, June 2007
- van Buijtenen, Jeroen; van As, Bart A. C.; Verbruggen, Marloes
- Journal of the American Chemical Society, Vol. 129, Issue 23
Precursor-Directed Biosynthesis of Erythromycin Analogs by an Engineered Polyketide Synthase
journal, July 1997
- Jacobsen, J. R.
- Science, Vol. 277, Issue 5324
Polyketides and their synthesis
patent, April 2007
- Leadlay, Peter Francis; Staunton, James; Cortes, Jesus
- US Patent Document 7,198,922
Recombinant production of novel polyketides
patent, November 1998
- Khosla, Chaitan; Hopwood, David A.; Ebert-Khosla, Suzanne
- US Patent Document 5,830,750
Izumenolide - a novel .BETA.-lactamase inhibitor produced by Micromonospora. II. Biological properties.
journal, January 1980
- Bush, Karen; Bonner, Daniel P.; Sykes, Richard B.
- The Journal of Antibiotics, Vol. 33, Issue 11
Fragrance precursors
patent, September 2005
- Gautschi, Markus; Plessis, Caroline; Derrer, Samuel
- US Patent Document 6,939,845
Anticancer agents, perfumes or foods and drinks
patent, October 2003
- Ito, Nobuhiko; Tsuji, Hiroyuki; Fukuda, Yoshio
- US Patent Document 6,639,089
Synthesis of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase: The ethylmalonyl-CoA pathway
journal, June 2007
- Erb, T. J.; Berg, I. A.; Brecht, V.
- Proceedings of the National Academy of Sciences, Vol. 104, Issue 25, p. 10631-10636
Recombinant production of novel polyketides
patent, December 1998
- Khosla, Chaitan; Hopwood, David A.; Ebert-Khosla, Susanne
- US Patent Document 5,843,718
A chain initiation factor common to both modular and aromatic polyketide synthases
journal, September 1999
- Bisang, Christian; Long, Paul F.; Corte´s, Jesús
- Nature, Vol. 401, Issue 6752
New silicon-mediated ring expansion of n-sized conjugated cycloalkenones into homoallylic n+3 lactones
journal, July 2003
- Hatcher, Mark A.; Borstnik, Kristina; Posner, Gary H.
- Tetrahedron Letters, Vol. 44, Issue 29, p. 5407-5409
The synthesis of 14-membered macrocyclic ethers
journal, November 1999
- Clyne, Dean; Weiler, Larry
- Tetrahedron, Vol. 55, Issue 48, p. 13659-13682
Food additive sanitizing compositions
patent, August 1993
- Richter, Francis L.; Pedersen, Daniel E.; Fredell, Dale L.
- US Patent Document 5,234,719
Recombinant methods and materials for producing epothilones C and D
patent, October 2001
- Julien, Bryan; Katz, Leonard; Khosla, Chaitan
- US Patent Document 6,303,342