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Title: Cellulases, nucleic acids encoding them and methods for making and using them

Abstract

This invention relates to molecular and cellular biology and biochemistry. In one aspect, the invention provides polypeptides having cellulase activity, e.g., endoglucanase, cellobiohydrolase, mannanase and/or .beta.-glucosidase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides cellulase activity, e.g., endoglucanase, cellobiohydrolase, mannanase and/or .beta.-glucosidase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural, food and feed processing and industrial contexts.

Inventors:
; ;
Issue Date:
Research Org.:
BP Corporation North America (Houston, TX); Verenium Corporation (San Diego, CA)
Sponsoring Org.:
USDOE
OSTI Identifier:
1083313
Patent Number(s):
8,426,184
Application Number:
11/908,672
Assignee:
BP Corporation North America (Houston, TX) Verenium Corporation (San Diego, CA);
DOE Contract Number:  
FG03-02ER83395
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Blum, David, Gemsch Cuenca, Joslin, and Dycaico, Mark. Cellulases, nucleic acids encoding them and methods for making and using them. United States: N. p., 2013. Web.
Blum, David, Gemsch Cuenca, Joslin, & Dycaico, Mark. Cellulases, nucleic acids encoding them and methods for making and using them. United States.
Blum, David, Gemsch Cuenca, Joslin, and Dycaico, Mark. Tue . "Cellulases, nucleic acids encoding them and methods for making and using them". United States. https://www.osti.gov/servlets/purl/1083313.
@article{osti_1083313,
title = {Cellulases, nucleic acids encoding them and methods for making and using them},
author = {Blum, David and Gemsch Cuenca, Joslin and Dycaico, Mark},
abstractNote = {This invention relates to molecular and cellular biology and biochemistry. In one aspect, the invention provides polypeptides having cellulase activity, e.g., endoglucanase, cellobiohydrolase, mannanase and/or .beta.-glucosidase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides cellulase activity, e.g., endoglucanase, cellobiohydrolase, mannanase and/or .beta.-glucosidase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural, food and feed processing and industrial contexts.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2013},
month = {4}
}

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Works referenced in this record:

Catalytic Plasticity of Fatty Acid Modification Enzymes Underlying Chemical Diversity of Plant Lipids
journal, November 1998


Practical limits of function prediction
journal, January 2000


Protein tolerance to random amino acid change
journal, June 2004

  • Guo, H. H.; Choe, J.; Loeb, L. A.
  • Proceedings of the National Academy of Sciences, Vol. 101, Issue 25, p. 9205-9210
  • DOI: 10.1073/pnas.0403255101

Developments in Directed Evolution for Improving Enzyme Functions
journal, August 2007

  • Sen, S.; Venkata Dasu, V.; Mandal, B.
  • Applied Biochemistry and Biotechnology, Vol. 143, Issue 3, p. 212-223
  • DOI: 10.1007/s12010-007-8003-4

Prediction of protein function from protein sequence and structure
journal, January 1999

  • Whisstock, James C.; Lesk, Arthur M.
  • Quarterly Reviews of Biophysics, Vol. 36, Issue 3, p. 307-340
  • DOI: 10.1017/S0033583503003901

Structure and mechanism of endo/exocellulase E4 from Thermomonospora fusca
journal, October 1997

  • Sakon, Joshua; Irwin, Diana; Wilson, David B.
  • Nature Structural Biology, Vol. 4, Issue 10
  • DOI: 10.1038/nsb1097-810

Crystal structure of the catalytic core domain of the family 6 cellobiohydrolase II, Cel6A, from Humicola insolens, at 1.92 Å resolution
journal, January 1999

  • Varrot, Annabelle; Hastrup, Sven; SchÜLein, Martin
  • Biochemical Journal, Vol. 337, Issue 2
  • DOI: 10.1042/bj3370297