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Title: Recombinant microorganisms for increased production of organic acids

Abstract

Disclosed are recombinant microorganisms for producing organic acids. The recombinant microorganisms express a polypeptide that has the enzymatic activity of an enzyme that is utilized in the pentose phosphate cycle. The recombinant microorganism may include recombinant Actinobacillus succinogenes that has been transformed to express a Zwischenferment (Zwf) gene. The recombinant microorganisms may be useful in fermentation processes for producing organic acids such as succinic acid and lactic acid. Also disclosed are novel plasmids that are useful for transforming microorganisms to produce recombinant microorganisms that express enzymes such as Zwf.

Inventors:
; ;
Issue Date:
Research Org.:
Michigan Biotechnology Institute (Lansing, MI)
Sponsoring Org.:
USDOE
OSTI Identifier:
1083279
Patent Number(s):
8,431,373
Application Number:
13/328,894
Assignee:
Michigan Biotechnology Institute (Lansing, MI)
DOE Contract Number:  
FC36-02GO12001
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Yi, Jian, Kleff, Susanne, and Guettler, Michael V. Recombinant microorganisms for increased production of organic acids. United States: N. p., 2013. Web.
Yi, Jian, Kleff, Susanne, & Guettler, Michael V. Recombinant microorganisms for increased production of organic acids. United States.
Yi, Jian, Kleff, Susanne, and Guettler, Michael V. Tue . "Recombinant microorganisms for increased production of organic acids". United States. https://www.osti.gov/servlets/purl/1083279.
@article{osti_1083279,
title = {Recombinant microorganisms for increased production of organic acids},
author = {Yi, Jian and Kleff, Susanne and Guettler, Michael V},
abstractNote = {Disclosed are recombinant microorganisms for producing organic acids. The recombinant microorganisms express a polypeptide that has the enzymatic activity of an enzyme that is utilized in the pentose phosphate cycle. The recombinant microorganism may include recombinant Actinobacillus succinogenes that has been transformed to express a Zwischenferment (Zwf) gene. The recombinant microorganisms may be useful in fermentation processes for producing organic acids such as succinic acid and lactic acid. Also disclosed are novel plasmids that are useful for transforming microorganisms to produce recombinant microorganisms that express enzymes such as Zwf.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2013},
month = {4}
}

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Works referenced in this record:

Actinobacillus succinogenes sp. nov., a novel succinic-acid-producing strain from the bovine rumen
journal, January 1999

  • Guettler, M. V.; Rumler, D.; Jain, M. K.
  • International Journal of Systematic Bacteriology, Vol. 49, Issue 1
  • DOI: 10.1099/00207713-49-1-207

Molecular characterization of the Escherichia coli K-12 zwf gene encoding glucose 6-phosphate dehydrogenase.
journal, February 1991


Biotechnology of succinic acid production and markets for derived industrial products
journal, May 1999

  • Zeikus, J. G.; Jain, M. K.; Elankovan, P.
  • Applied Microbiology and Biotechnology, Vol. 51, Issue 5
  • DOI: 10.1007/s002530051431

Environmental and physiological factors affecting the succinate product ratio during carbohydrate fermentation by Actinobacillus sp. 130Z
journal, May 1997

  • der Werf, M. J. Van; Guettler, Michael V.; Jain, Mahendra K.
  • Archives of Microbiology, Vol. 167, Issue 6
  • DOI: 10.1007/s002030050452

Construction of a shuttle vector for the overexpression of recombinant proteins in Actinobacillus succinogenes
journal, March 2004