Microbes encapsulated within crosslinkable polymers

Title: Microbes encapsulated within crosslinkable polymers

Abstract

The invention relates to porous films comprising crosslinked electrospun hydrogel fibers. Viable microbes are encapsulated within the crosslinked electrospun hydrogel fibers. The crosslinked electrospun hydrogel fibers are water insoluble and permeable. The invention also relates to methods of making and using such porous films.

Inventors:: Chidambaram, Devicharan; Liu, Ying; Rafailovich, Miriam H

Issue Date:: 2013-02-05

Research Org.:: Brookhaven National Lab. (BNL), Upton, NY (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1083227

Patent Number(s):: 8367109

Application Number:: 12/420,088

Assignee:: Brookhaven Science Associates, LLC (Upton, NY); The Research Foundation of State University of New York (Stony Brook, NY)

Patent Classifications (CPCs):: G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

C - CHEMISTRY C08 - ORGANIC MACROMOLECULAR COMPOUNDS C08L - COMPOSITIONS OF MACROMOLECULAR COMPOUNDS

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G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N2520/00 - Use of whole organisms as detectors of pollution

C - CHEMISTRY C08 - ORGANIC MACROMOLECULAR COMPOUNDS C08L - COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
C08L2666/02 - Organic macromolecular compounds, natural resins, waxes or and bituminous materials
C08L51/08 - grafted on to macromolecular compounds obtained otherwise than by reactions only involving unsaturated carbon-to-carbon bonds
C08L51/003 - {grafted on to macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds

C - CHEMISTRY C08 - ORGANIC MACROMOLECULAR COMPOUNDS C08F - MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
C08F290/061 - {Polyesters

D - TEXTILES D01 - NATURAL OR MAN-MADE THREADS OR FIBRES D01D - MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
D01D5/003 - {the material being a polymer solution or dispersion

C - CHEMISTRY C08 - ORGANIC MACROMOLECULAR COMPOUNDS C08F - MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
C08F283/00 - Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G
C08F289/00 - Macromolecular compounds obtained by polymerising monomers on to macromolecular compounds not provided for in groups C08F251/00 - C08F287/00

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K35/74 - Bacteria

C - CHEMISTRY C08 - ORGANIC MACROMOLECULAR COMPOUNDS C08L - COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
C08L53/00 - Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
Y10T428/249921 - Web or sheet containing structurally defined element or component

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C12N11/04 - entrapped within the carrier, e.g. gel or hollow fibres

C - CHEMISTRY C02 - TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE C02F - TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
C02F3/00 - Biological treatment of water, waste water, or sewage {

C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
C12Q1/02 - involving viable microorganisms

C - CHEMISTRY C02 - TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE C02F - TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
C02F3/108 - {Immobilising gels, polymers or the like}

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K9/0024 - {Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
Y10T428/268 - Monolayer with structurally defined element

C - CHEMISTRY C02 - TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE C02F - TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
C02F3/34 - characterised by the microorganisms used

D - TEXTILES D01 - NATURAL OR MAN-MADE THREADS OR FIBRES D01F - CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
D01F6/66 - from polyethers

C - CHEMISTRY C08 - ORGANIC MACROMOLECULAR COMPOUNDS C08F - MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
C08F290/06 - Polymers provided for in subclass C08G

D - TEXTILES D01 - NATURAL OR MAN-MADE THREADS OR FIBRES D01F - CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
D01F1/10 - Other agents for modifying properties

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K9/7007 - {Drug-containing films, membranes or sheets
A61K36/06 - Fungi, e.g. yeasts
A61K35/747 - Lactobacilli, e.g. L. acidophilus or L. brevis

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y02 - TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE Y02W - CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO WASTEWATER TREATMENT OR WASTE MANAGEMENT
Y02W10/10 - Biological treatment of water, waste water, or sewage

D - TEXTILES D01 - NATURAL OR MAN-MADE THREADS OR FIBRES D01F - CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
D01F11/08 - of macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K35/745 - Bifidobacteria
A61K47/10 - Alcohols
A61K35/744 - Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P1/00 - Drugs for disorders of the alimentary tract or the digestive system

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DOE Contract Number:: AC02-98CH10886

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES

Citation Formats


                    Chidambaram, Devicharan, Liu, Ying, and Rafailovich, Miriam H. Microbes encapsulated within crosslinkable polymers.  United States: N. p., 2013. 
        Web.

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                    Chidambaram, Devicharan, Liu, Ying, & Rafailovich, Miriam H. Microbes encapsulated within crosslinkable polymers.  United States.

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                    Chidambaram, Devicharan, Liu, Ying, and Rafailovich, Miriam H. Tue .  
        "Microbes encapsulated within crosslinkable polymers".  United States.  https://www.osti.gov/servlets/purl/1083227.

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@article{osti_1083227,

  title        = {Microbes encapsulated within crosslinkable polymers},

  author       = {Chidambaram, Devicharan and Liu, Ying and Rafailovich, Miriam H},

  abstractNote = {The invention relates to porous films comprising crosslinked electrospun hydrogel fibers. Viable microbes are encapsulated within the crosslinked electrospun hydrogel fibers. The crosslinked electrospun hydrogel fibers are water insoluble and permeable. The invention also relates to methods of making and using such porous films.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2013},

  month        = {2}

}

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Works referenced in this record:

Microbial sensor for aspartame
journal, February 1985

Renneberg, R.; Riedel, K.; Scheller, F.
Applied Microbiology and Biotechnology, Vol. 21, Issue 3-4
https://doi.org/10.1007/BF00295116

Smart Hydrogels for in Situ Generated Implants ^†
journal, May 2005

Cohn, Daniel; Sosnik, Alejandro; Garty, Shai
Biomacromolecules, Vol. 6, Issue 3
https://doi.org/10.1021/bm0495250

Novel Biohybrid Materials by Electrospinning: Nanofibers of Poly(ethylene oxide) and Living Bacteria
journal, September 2007

Gensheimer, M.; Becker, M.; Brandis-Heep, A.
Advanced Materials, Vol. 19, Issue 18
https://doi.org/10.1002/adma.200602936

Structure and Nanomechanical Characterization of Electrospun PS/Clay Nanocomposite Fibers
journal, January 2006

Ji, Yuan; Li, Bingquan; Ge, Shouren
Langmuir, Vol. 22, Issue 3
https://doi.org/10.1021/la0525022

Encapsulation of bacteria and viruses in electrospun nanofibres
journal, August 2006

Salalha, W.; Kuhn, J.; Dror, Y.
Nanotechnology, Vol. 17, Issue 18
https://doi.org/10.1088/0957-4484/17/18/025

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Similar Records

Title: Microbes encapsulated within crosslinkable polymers

Abstract

Citation Formats

Microbial sensor for aspartame journal, February 1985

Smart Hydrogels for in Situ Generated Implants † journal, May 2005

Novel Biohybrid Materials by Electrospinning: Nanofibers of Poly(ethylene oxide) and Living Bacteria journal, September 2007

Structure and Nanomechanical Characterization of Electrospun PS/Clay Nanocomposite Fibers journal, January 2006

Encapsulation of bacteria and viruses in electrospun nanofibres journal, August 2006

Microbial sensor for aspartame
journal, February 1985

Smart Hydrogels for in Situ Generated Implants ^†
journal, May 2005

Novel Biohybrid Materials by Electrospinning: Nanofibers of Poly(ethylene oxide) and Living Bacteria
journal, September 2007

Structure and Nanomechanical Characterization of Electrospun PS/Clay Nanocomposite Fibers
journal, January 2006

Encapsulation of bacteria and viruses in electrospun nanofibres
journal, August 2006