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Title: Study of polymer molecules and conformations with a nanopore

Abstract

The invention features methods for evaluating the conformation of a polymer, for example, for determining the conformational distribution of a plurality of polymers and to detect binding or denaturation events. The methods employ a nanopore which the polymer, e.g., a nucleic acid, traverses. As the polymer traverses the nanopore, measurements of transport properties of the nanopore yield data on the conformation of the polymer.

Inventors:
; ; ;
Issue Date:
Research Org.:
Harvard Univ., Cambridge, MA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1083056
Patent Number(s):
8394640
Application Number:
12/961,021
Assignee:
President and Fellows of Harvard College (Cambridge, MA)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
FG02-01ER45922
Resource Type:
Patent
Resource Relation:
Patent File Date: 2010 Dec 06
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Golovchenko, Jene A., Li, Jiali, Stein, Derek, and Gershow, Marc H. Study of polymer molecules and conformations with a nanopore. United States: N. p., 2013. Web.
Golovchenko, Jene A., Li, Jiali, Stein, Derek, & Gershow, Marc H. Study of polymer molecules and conformations with a nanopore. United States.
Golovchenko, Jene A., Li, Jiali, Stein, Derek, and Gershow, Marc H. Tue . "Study of polymer molecules and conformations with a nanopore". United States. https://www.osti.gov/servlets/purl/1083056.
@article{osti_1083056,
title = {Study of polymer molecules and conformations with a nanopore},
author = {Golovchenko, Jene A. and Li, Jiali and Stein, Derek and Gershow, Marc H.},
abstractNote = {The invention features methods for evaluating the conformation of a polymer, for example, for determining the conformational distribution of a plurality of polymers and to detect binding or denaturation events. The methods employ a nanopore which the polymer, e.g., a nucleic acid, traverses. As the polymer traverses the nanopore, measurements of transport properties of the nanopore yield data on the conformation of the polymer.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2013},
month = {3}
}

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