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Title: High density growth of T7 expression strains with auto-induction option

A method for promoting and suppressing auto-induction of transcription of a cloned gene 1 of bacteriophage T7 in cultures of bacterial cells grown batchwise is disclosed. The transcription is under the control of a promoter whose activity can be induced by an exogenous inducer whose ability to induce said promoter is dependent on the metabolic state of said bacterial cells.
Inventors:
Issue Date:
OSTI Identifier:
1083033
Assignee:
Brookhaven Science Associates, LLC (Upton, NY) BNL
Patent Number(s):
8,399,217
Application Number:
11/741,282
Contract Number:
AC02-98CH10886
Research Org:
BNL (Brookhaven National Laboratory (BNL), Upton, NY (United States))
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES