DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Means and methods for cytometric therapies

Abstract

A functionalized tip is incorporated into catheters for the cytometric delivery of cells into the brain and other body parts. For use in the brain, the tip forms part of a neurosurgical probe having a proximal end and a distal end. In addition to the functionalized tip, the probe has at least one cell slurry delivery lumen and a plurality of optical fibers configured along the probe, terminating in the tip to provide the photo-optical capability needed to monitor the viability and physiological behavior of the grafted cells as well as certain characteristics of the cellular environment. Details are also presented of the use of a neurocatheter having a cytometric tip of the type disclosed in the invention, as employed within the context of a feedback and control system for regulating the number of cells delivered to the brain of a patient.

Inventors:
; ; ; ;
Issue Date:
Research Org.:
ORO (Oak Ridge Office, Oak Ridge, TN (United States))
Sponsoring Org.:
USDOE
OSTI Identifier:
1083012
Patent Number(s):
8406837
Application Number:
12/513,258
Assignee:
UT-Battelle, LLC (Oak Ridge, TN) ; University of Virginia Patent Foundation (Charlottesville, VA)
DOE Contract Number:  
AC05-00OR22725
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Gillies, George T., Fillmore, Helen, Broaddus, William C., Evans, III, Boyd M., and Allison, Stephen W. Means and methods for cytometric therapies. United States: N. p., 2013. Web.
Gillies, George T., Fillmore, Helen, Broaddus, William C., Evans, III, Boyd M., & Allison, Stephen W. Means and methods for cytometric therapies. United States.
Gillies, George T., Fillmore, Helen, Broaddus, William C., Evans, III, Boyd M., and Allison, Stephen W. Tue . "Means and methods for cytometric therapies". United States. https://www.osti.gov/servlets/purl/1083012.
@article{osti_1083012,
title = {Means and methods for cytometric therapies},
author = {Gillies, George T. and Fillmore, Helen and Broaddus, William C. and Evans, III, Boyd M. and Allison, Stephen W.},
abstractNote = {A functionalized tip is incorporated into catheters for the cytometric delivery of cells into the brain and other body parts. For use in the brain, the tip forms part of a neurosurgical probe having a proximal end and a distal end. In addition to the functionalized tip, the probe has at least one cell slurry delivery lumen and a plurality of optical fibers configured along the probe, terminating in the tip to provide the photo-optical capability needed to monitor the viability and physiological behavior of the grafted cells as well as certain characteristics of the cellular environment. Details are also presented of the use of a neurocatheter having a cytometric tip of the type disclosed in the invention, as employed within the context of a feedback and control system for regulating the number of cells delivered to the brain of a patient.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2013},
month = {3}
}

Works referenced in this record: