Labeled ALPHA4BETA2 ligands and methods therefor
Abstract
Contemplated compositions and methods are employed to bind in vitro and in vivo to an .alpha.4.beta.2 nicotinic acetylcholine receptor in a highly selective manner. Where such compounds are labeled, compositions and methods employing such compounds can be used for PET and SPECT analysis. Alternatively, and/or additionally contemplated compounds can be used as antagonists, partial agonists or agonists in the treatment of diseases or conditions associated with .alpha.4.beta..beta.2 dysfunction.
- Inventors:
- Issue Date:
- Research Org.:
- DOESC (USDOE Office of Science (SC) (United States))
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1082891
- Patent Number(s):
- 8378109
- Application Number:
- 11/721,145
- Assignee:
- The Regents of the University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- DOE Contract Number:
- FG02-03ER63598
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES
Citation Formats
Mukherjee, Jogeshwar, Pichika, Ramaiah, Potkin, Steven, Leslie, Frances, and Chattopadhyay, Sankha. Labeled ALPHA4BETA2 ligands and methods therefor. United States: N. p., 2013.
Web.
Mukherjee, Jogeshwar, Pichika, Ramaiah, Potkin, Steven, Leslie, Frances, & Chattopadhyay, Sankha. Labeled ALPHA4BETA2 ligands and methods therefor. United States.
Mukherjee, Jogeshwar, Pichika, Ramaiah, Potkin, Steven, Leslie, Frances, and Chattopadhyay, Sankha. Tue .
"Labeled ALPHA4BETA2 ligands and methods therefor". United States. https://www.osti.gov/servlets/purl/1082891.
@article{osti_1082891,
title = {Labeled ALPHA4BETA2 ligands and methods therefor},
author = {Mukherjee, Jogeshwar and Pichika, Ramaiah and Potkin, Steven and Leslie, Frances and Chattopadhyay, Sankha},
abstractNote = {Contemplated compositions and methods are employed to bind in vitro and in vivo to an .alpha.4.beta.2 nicotinic acetylcholine receptor in a highly selective manner. Where such compounds are labeled, compositions and methods employing such compounds can be used for PET and SPECT analysis. Alternatively, and/or additionally contemplated compounds can be used as antagonists, partial agonists or agonists in the treatment of diseases or conditions associated with .alpha.4.beta..beta.2 dysfunction.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Feb 19 00:00:00 EST 2013},
month = {Tue Feb 19 00:00:00 EST 2013}
}
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