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Title: Labeled ALPHA4BETA2 ligands and methods therefor

Abstract

Contemplated compositions and methods are employed to bind in vitro and in vivo to an .alpha.4.beta.2 nicotinic acetylcholine receptor in a highly selective manner. Where such compounds are labeled, compositions and methods employing such compounds can be used for PET and SPECT analysis. Alternatively, and/or additionally contemplated compounds can be used as antagonists, partial agonists or agonists in the treatment of diseases or conditions associated with .alpha.4.beta..beta.2 dysfunction.

Inventors:
; ; ; ;
Issue Date:
Research Org.:
DOESC (USDOE Office of Science (SC) (United States))
Sponsoring Org.:
USDOE
OSTI Identifier:
1082891
Patent Number(s):
8378109
Application Number:
11/721,145
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
DOE Contract Number:  
FG02-03ER63598
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Mukherjee, Jogeshwar, Pichika, Ramaiah, Potkin, Steven, Leslie, Frances, and Chattopadhyay, Sankha. Labeled ALPHA4BETA2 ligands and methods therefor. United States: N. p., 2013. Web.
Mukherjee, Jogeshwar, Pichika, Ramaiah, Potkin, Steven, Leslie, Frances, & Chattopadhyay, Sankha. Labeled ALPHA4BETA2 ligands and methods therefor. United States.
Mukherjee, Jogeshwar, Pichika, Ramaiah, Potkin, Steven, Leslie, Frances, and Chattopadhyay, Sankha. Tue . "Labeled ALPHA4BETA2 ligands and methods therefor". United States. https://www.osti.gov/servlets/purl/1082891.
@article{osti_1082891,
title = {Labeled ALPHA4BETA2 ligands and methods therefor},
author = {Mukherjee, Jogeshwar and Pichika, Ramaiah and Potkin, Steven and Leslie, Frances and Chattopadhyay, Sankha},
abstractNote = {Contemplated compositions and methods are employed to bind in vitro and in vivo to an .alpha.4.beta.2 nicotinic acetylcholine receptor in a highly selective manner. Where such compounds are labeled, compositions and methods employing such compounds can be used for PET and SPECT analysis. Alternatively, and/or additionally contemplated compounds can be used as antagonists, partial agonists or agonists in the treatment of diseases or conditions associated with .alpha.4.beta..beta.2 dysfunction.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2013},
month = {2}
}

Works referenced in this record:

Heterocyclic ether compounds useful in controlling neurotransmitter release
patent, June 1999


Development of ligands for in vivo imaging of cerebral nicotinic receptors
journal, August 2000


Nicotinic receptor antagonists in the treatment of neuropharmacological disorders
patent, November 1997