Systems for the expression of orthogonal translation components in eubacterial host cells

Ryu, Youngha; Schultz, Peter G.

Advanced Search OptionsAdvanced Search queries use a traditional Term Search. For more info, see our FAQ.

All Fields:

Patent Title:

Abstract:

Assignee:

Inventor(s):

Patent Number:

Patent Classification (CPC):

All Classifications
A - human necessities
A01 - agriculture
A21 - baking
A22 - butchering
A23 - foods or foodstuffs
A24 - tobacco
A41 - wearing apparel
A42 - headwear
A43 - footwear
A44 - haberdashery
A45 - hand or travelling articles
A46 - brushware
A47 - furniture
A61 - medical or veterinary science
A62 - life-saving
A63 - sports
A99 - subject matter not otherwise provided for in this section
B - performing operations
B01 - physical or chemical processes or apparatus in general
B02 - crushing, pulverising, or disintegrating
B03 - separation of solid materials using liquids or using pneumatic tables or jigs
B04 - centrifugal apparatus or machines for carrying-out physical or chemical processes
B05 - spraying or atomising in general
B06 - generating or transmitting mechanical vibrations in general
B07 - separating solids from solids
B08 - cleaning
B09 - disposal of solid waste
B21 - mechanical metal-working without essentially removing material
B22 - casting
B23 - machine tools
B24 - grinding
B25 - hand tools
B26 - hand cutting tools
B27 - working or preserving wood or similar material
B28 - working cement, clay, or stone
B29 - working of plastics
B30 - presses
B31 - making articles of paper, cardboard or material worked in a manner analogous to paper
B32 - layered products
B33 - additive manufacturing technology
B41 - printing
B42 - bookbinding
B43 - writing or drawing implements
B44 - decorative arts
B60 - vehicles in general
B61 - railways
B62 - land vehicles for travelling otherwise than on rails
B63 - ships or other waterborne vessels
B64 - aircraft
B65 - conveying
B66 - hoisting
B67 - opening, closing {or cleaning} bottles, jars or similar containers
B68 - saddlery
B81 - microstructural technology
B82 - nanotechnology
B99 - subject matter not otherwise provided for in this section
C - chemistry
C01 - inorganic chemistry
C02 - treatment of water, waste water, sewage, or sludge
C03 - glass
C04 - cements
C05 - fertilisers
C06 - explosives
C07 - organic chemistry
C08 - organic macromolecular compounds
C09 - dyes
C10 - petroleum, gas or coke industries
C11 - animal or vegetable oils, fats, fatty substances or waxes
C12 - biochemistry
C13 - sugar industry
C14 - skins
C21 - metallurgy of iron
C22 - metallurgy
C23 - coating metallic material
C25 - electrolytic or electrophoretic processes
C30 - crystal growth
C40 - combinatorial technology
C99 - subject matter not otherwise provided for in this section
D - textiles
D01 - natural or man-made threads or fibres
D02 - yarns
D03 - weaving
D04 - braiding
D05 - sewing
D06 - treatment of textiles or the like
D07 - ropes
D10 - indexing scheme associated with sublasses of section d, relating to textiles
D21 - paper-making
D99 - subject matter not otherwise provided for in this section
E - fixed constructions
E01 - construction of roads, railways, or bridges
E02 - hydraulic engineering
E03 - water supply
E04 - building
E05 - locks
E06 - doors, windows, shutters, or roller blinds in general
E21 - earth drilling
E99 - subject matter not otherwise provided for in this section
F - mechanical engineering
F01 - machines or engines in general
F02 - combustion engines
F03 - machines or engines for liquids
F04 - positive - displacement machines for liquids
F05 - indexing schemes relating to engines or pumps in various subclasses of classes f01-f04
F15 - fluid-pressure actuators
F16 - engineering elements and units
F17 - storing or distributing gases or liquids
F21 - lighting
F22 - steam generation
F23 - combustion apparatus
F24 - heating
F25 - refrigeration or cooling
F26 - drying
F27 - furnaces
F28 - heat exchange in general
F41 - weapons
F42 - ammunition
F99 - subject matter not otherwise provided for in this section
G - physics
G01 - measuring
G02 - optics
G03 - photography
G04 - horology
G05 - controlling
G06 - computing
G07 - checking-devices
G08 - signalling
G09 - education
G10 - musical instruments
G11 - information storage
G12 - instrument details
G16 - information and communication technology [ict] specially adapted for specific application fields
G21 - nuclear physics
G99 - subject matter not otherwise provided for in this section
H - electricity
H01 - basic electric elements
H02 - generation
H03 - basic electronic circuitry
H04 - electric communication technique
H05 - electric techniques not otherwise provided for
H99 - subject matter not otherwise provided for in this section
Y - new / cross sectional technologies
Y02 - technologies or applications for mitigation or adaptation against climate change
Y04 - information or communication technologies having an impact on other technology areas
Y10 - technical subjects covered by former uspc

More Options ...

Title: Systems for the expression of orthogonal translation components in eubacterial host cells

Abstract

The invention related to compositions and methods for the in vivo production of polypeptides comprising one or more unnatural amino acids. Specifically, the invention provides plasmid systems for the efficient eubacterial expression of polypeptides comprising one or more unnatural acids at genetically-programmed positions.

Inventors:: Ryu, Youngha; Schultz, Peter G.

Issue Date:: Tue Jan 22 00:00:00 EST 2013

Research Org.:: The Scripps Research Institute (LaJolla, CA)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1082729

Patent Number(s):: 8357512

Application Number:: 13/468,736

Assignee:: The Scripps Research Institute (LaJolla, CA)

Patent Classifications (CPCs):: C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

Show more

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C07K14/245 - Escherichia

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C12N15/70 - Vectors or expression systems specially adapted for E. coli

C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
C12P21/02 - having a known sequence of two or more amino acids, e.g. glutathione

Show less

DOE Contract Number:: FG02-03ER46051

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES

Citation Formats


                    Ryu, Youngha, and Schultz, Peter G. Systems for the expression of orthogonal translation components in eubacterial host cells.  United States: N. p., 2013. 
        Web.

Copy to clipboard


                    Ryu, Youngha, & Schultz, Peter G. Systems for the expression of orthogonal translation components in eubacterial host cells.  United States.

Copy to clipboard


                    Ryu, Youngha, and Schultz, Peter G. Tue .  
        "Systems for the expression of orthogonal translation components in eubacterial host cells".  United States.  https://www.osti.gov/servlets/purl/1082729.

Copy to clipboard


                    
@article{osti_1082729,

  title        = {Systems for the expression of orthogonal translation components in eubacterial host cells},

  author       = {Ryu, Youngha and Schultz, Peter G.},

  abstractNote = {The invention related to compositions and methods for the in vivo production of polypeptides comprising one or more unnatural amino acids. Specifically, the invention provides plasmid systems for the efficient eubacterial expression of polypeptides comprising one or more unnatural acids at genetically-programmed positions.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Jan 22 00:00:00 EST 2013},

  month        = {Tue Jan 22 00:00:00 EST 2013}

}

Copy to clipboard

Patent:

Save / Share:

Export Metadata

Save to My Library

Works referenced in this record:

Glycoprotein synthesis
patent-application, July 2007

Schultz, Peter; Wang, Lei; Zhang, Zhiwen
US Patent Application 11/580203; 20070172915
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20070172915

Unnatural reactive amino acid genetic code additions
patent-application, December 2004

Deiters, Alexander; Cropp, T. Ashton; Chin, Jason W.
US Patent Application 10/826919; 20040265952
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20040265952

A Genetically Encoded Photocaged Amino Acid
journal, November 2004

Wu, Ning; Deiters, Alexander; Cropp, T. Ashton
Journal of the American Chemical Society, Vol. 126, Issue 44
https://doi.org/10.1021/ja040175z

Genomic organization and physical mapping of the transfer RNA genes in Escherichia coli K12
journal, April 1990

Komine, Yuriko; Adachi, Toshiharu; Inokuchi, Hachiro
Journal of Molecular Biology, Vol. 212, Issue 4
https://doi.org/10.1016/0022-2836(90)90224-A

Manipulation of microparticles in microfluidic systems
patent-application, May 2004

Burd Mehta, Tammy; Kopf-Sill, Anne R.; Parce, J. Wallace
US Patent Application 10/606201; 20040096960
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20040096960

Site specific incorporation of keto amino acids into proteins
patent-application, March 2006

Schultz, Peter G.; Wang, Lei
US Patent Application 10/530421; 20060068478
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20060068478

Glycoprotein synthesis
patent, February 2007

Schultz, Peter G.; Wang, Lei; Zhang, Zhiwen
US Patent Document 7,183,082
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7183082

Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells
patent-application, May 2007

Zhang, Zhiwen; Alfonta, Lital; Schultz, Peter
US Patent Application 10/580987; 20070111193
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20070111193

Expanding the eukaryotic genetic code
patent-application, January 2005

Chin, Jason W.; Cropp, T. Ashton; Anderson, J. Christopher
US Patent Application 10/825867; 20050009049
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20050009049

Site-Specific Incorporation of a Redox-Active Amino Acid into Proteins
journal, December 2003

Alfonta, Lital; Zhang, Zhiwen; Uryu, Sean
Journal of the American Chemical Society, Vol. 125, Issue 48, p. 14662-14663
https://doi.org/10.1021/ja038242x

Adding amino acids to the genetic repertoire
journal, December 2005

Xie, Jianming; Schultz, Peter G.
Current Opinion in Chemical Biology, Vol. 9, Issue 6, p. 548-554
https://doi.org/10.1016/j.cbpa.2005.10.011

A New Strategy for the Synthesis of Glycoproteins
journal, January 2004

Zhang, Z.
Science, Vol. 303, Issue 5656
https://doi.org/10.1126/science.1089509

Compositions of orthogonal leucyl-trna and aminoacyl-trna synthetase pairs and uses thereof
patent-application, July 2006

Anderson, J. Christopher; Schultz, Peter G.
US Patent Application 10/563655; 20060160175
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20060160175

FIS activates sequential steps during transcription initiation at a stable RNA promoter
journal, June 1997

Muskhelishvili, G.
The EMBO Journal, Vol. 16, Issue 12
https://doi.org/10.1093/emboj/16.12.3655

Microfabricated cell injector
patent, January 2005

Garman, Andrew J.; Scanlon, David J.; Dodgson, John
US Patent Document 6,846,668
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6846668

Site-specific labeling of proteins for NMR studies
patent-application, May 2006

Deiters, Alexander; Geierstanger, Bernhard H.; Schultz, Peter G.
US Patent Application 11/233466; 20060110784
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20060110784

A general approach for the generation of orthogonal tRNAs
journal, September 2001

Wang, Lei; Schultz, Peter G.
Chemistry & Biology, Vol. 8, Issue 9, p. 883-890
https://doi.org/10.1016/S1074-5521(01)00063-1

Site-specific incorporation of redox active amino acids into proteins
patent-application, October 2005

Alfonta, Lital; Schultz, Peter G.; Zhang, Zhiwen
US Patent Application 10/965218; 20050227318
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20050227318

Selective posttranslational modification of phage-displayed polypeptides
patent-application, August 2007

Tsao, Meng-Lin; Tian, Feng; Schultz, Peter
US Patent Application 11/580223; 20070178448
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20070178448

Orthogonal Translation Components for the in Vivo Incorporation of Unnatural Amino Acids
patent-application, September 2008

Schultz, Peter G.; Alfonta, Lital; Chittuluru, Jonathan R.
US Patent Application 11/665083; 20080233611
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20080233611

Glycoprotein synthesis
patent, April 2007

Shultz, Peter G.; Wang, Lei; Zhang, Zhiwen
US Patent Document 7,199,222
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7199222

Site specific incorporation of heavy atom-containing unnatural amino acids into proteins for structure determination
patent-application, December 2005

Xie, Jianming; Wang, Lei; Wu, Ning
US Patent Application 11/137850; 20050272121
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20050272121

Site-specific incorporation of redox active amino acids into proteins
patent-application, January 2007

Alfonta, Lital; Schultz, Peter G.; Zhang, Zhiwen
US Patent Application 10/575991; 20070009990
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20070009990

Expanding the eukaryotic genetic code
patent-application, July 2007

Chin, Jason; Cropp, T. Ashton; Anderson, J. Christopher
US Patent Application 11/710672; 20070166791
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20070166791

Compositions of orthogonal lysyl-trna and aminoacyl-trna synthetase pairs and uses thereof
patent-application, February 2007

Anderson, J. Christopher; Wu, Ning; Santoro, Stephen
US Patent Application 10/563686; 20070042461
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20070042461