Anti-cancer agents based on 4-(hetero)Ary1-1,2,5-oxadiazol-3-yl Amino derivatives and a method of making
Abstract
The present disclosure relates to novel compounds that can be used as anti-cancer agents in the prostate cancer therapy. ##STR00001## In particular, the invention relates N-substituted derivatives of 4-(hetero)aryl-1,2,5-oxadiazol-3-yl amines having the structural Formula (I) and (II), stereoisomers, tautomers, racemics, prodrugs, metabolites thereof, or pharmaceutically acceptable salt and/or solvate thereof. Meaning of R1 and R2 in the Formula (I) and (II) are defined in claim 1. The invention also relates to methods for preparing said compounds, and to pharmaceutical compositions comprising said compounds.
- Inventors:
- Issue Date:
- Research Org.:
- US Department of Energy (USDOE), Washington, DC (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1082680
- Patent Number(s):
- 8362047
- Application Number:
- 12/822,243
- Assignee:
- U.S. Department of Energy (Washington, DC)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
- DOE Contract Number:
- 3548
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2010 Jun 24
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES
Citation Formats
Gakh, Andrei A., Krasavin, Mikhail, Karapetian, Ruben, Rufanov, Konstantin A., Konstantinov, Igor, Godovykh, Elena, Soldatkina, Olga, and Sosnov, Andrey V. Anti-cancer agents based on 4-(hetero)Ary1-1,2,5-oxadiazol-3-yl Amino derivatives and a method of making. United States: N. p., 2013.
Web.
Gakh, Andrei A., Krasavin, Mikhail, Karapetian, Ruben, Rufanov, Konstantin A., Konstantinov, Igor, Godovykh, Elena, Soldatkina, Olga, & Sosnov, Andrey V. Anti-cancer agents based on 4-(hetero)Ary1-1,2,5-oxadiazol-3-yl Amino derivatives and a method of making. United States.
Gakh, Andrei A., Krasavin, Mikhail, Karapetian, Ruben, Rufanov, Konstantin A., Konstantinov, Igor, Godovykh, Elena, Soldatkina, Olga, and Sosnov, Andrey V. Tue .
"Anti-cancer agents based on 4-(hetero)Ary1-1,2,5-oxadiazol-3-yl Amino derivatives and a method of making". United States. https://www.osti.gov/servlets/purl/1082680.
@article{osti_1082680,
title = {Anti-cancer agents based on 4-(hetero)Ary1-1,2,5-oxadiazol-3-yl Amino derivatives and a method of making},
author = {Gakh, Andrei A. and Krasavin, Mikhail and Karapetian, Ruben and Rufanov, Konstantin A. and Konstantinov, Igor and Godovykh, Elena and Soldatkina, Olga and Sosnov, Andrey V.},
abstractNote = {The present disclosure relates to novel compounds that can be used as anti-cancer agents in the prostate cancer therapy. ##STR00001## In particular, the invention relates N-substituted derivatives of 4-(hetero)aryl-1,2,5-oxadiazol-3-yl amines having the structural Formula (I) and (II), stereoisomers, tautomers, racemics, prodrugs, metabolites thereof, or pharmaceutically acceptable salt and/or solvate thereof. Meaning of R1 and R2 in the Formula (I) and (II) are defined in claim 1. The invention also relates to methods for preparing said compounds, and to pharmaceutical compositions comprising said compounds.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jan 29 00:00:00 EST 2013},
month = {Tue Jan 29 00:00:00 EST 2013}
}
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