Title: Crystal of GTP Cyclohydrolase Type IB

Abstract

This invention relates to a novel, bacterial GTP Cyclohydrolase Type IB enzyme, and the crystal structure thereof.

Inventors:

Swairjo, Manal A.; Iwata-Reuyl, Dirk; de Crecy-Lagard, Valerie

Issue Date:

Tue Dec 11 00:00:00 EST 2012

Research Org.:

SLAC (SLAC National Accelerator Laboratory (SLAC), Menlo Park, CA (United States))

Sponsoring Org.:

USDOE

OSTI Identifier:

1082460

Patent Number(s):

8328934

Application Number:

12/756,617

Assignee:

Western University of Health Sciences (Pomona, CA)

Patent Classifications (CPCs):

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

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C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES

C07K14/22 - from Neisseriaceae
C07K2299/00 - Coordinates from 3D structures of peptides, e.g. proteins or enzymes

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

C12N9/78 - acting on carbon to nitrogen bonds other than peptide bonds

C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS

C12Q1/34 - involving hydrolase

C - CHEMISTRY C12 - BIOCHEMISTRY C12Y - ENZYMES

C12Y305/04016 - GTP cyclohydrolase I

G - PHYSICS G16 - INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS G16B - BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY

G16B15/30 - Drug targeting using structural data
G16B5/00 - ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks

G - PHYSICS G16 - INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS G16C - COMPUTATIONAL CHEMISTRY

G16C20/50 - Molecular design, e.g. of drugs
G16C99/00 - Subject matter not provided for in other groups of this subclass

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Resource Type:

Patent

Country of Publication:

United States

Language:

English

Subject:

59 BASIC BIOLOGICAL SCIENCES