Method to determine transcriptional regulation pathways in organisms
Abstract
The invention relates to computer-implemented methods and systems for identifying regulatory relationships between expressed regulating polypeptides and targets of the regulatory activities of such regulating polypeptides. More specifically, the invention provides a new method for identifying regulatory dependencies between biochemical species in a cell. In particular embodiments, provided are computer-implemented methods for identifying a regulatory interaction between a transcription factor and a gene target of the transcription factor, or between a transcription factor and a set of gene targets of the transcription factor. Further provided are genome-scale methods for predicting regulatory interactions between a set of transcription factors and a corresponding set of transcriptional target substrates thereof.
- Inventors:
- Issue Date:
- Research Org.:
- Boston University (Boston, MA)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1080438
- Patent Number(s):
- 8306752
- Application Number:
- 12/271,944
- Assignee:
- Trustees of Boston University (Boston, MA)
- Patent Classifications (CPCs):
-
G - PHYSICS G16 - INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS G16B - BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- DOE Contract Number:
- FG02-04ER63803
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Gardner, Timothy S., Collins, James J., Hayete, Boris, and Faith, Jeremiah. Method to determine transcriptional regulation pathways in organisms. United States: N. p., 2012.
Web.
Gardner, Timothy S., Collins, James J., Hayete, Boris, & Faith, Jeremiah. Method to determine transcriptional regulation pathways in organisms. United States.
Gardner, Timothy S., Collins, James J., Hayete, Boris, and Faith, Jeremiah. Tue .
"Method to determine transcriptional regulation pathways in organisms". United States. https://www.osti.gov/servlets/purl/1080438.
@article{osti_1080438,
title = {Method to determine transcriptional regulation pathways in organisms},
author = {Gardner, Timothy S. and Collins, James J. and Hayete, Boris and Faith, Jeremiah},
abstractNote = {The invention relates to computer-implemented methods and systems for identifying regulatory relationships between expressed regulating polypeptides and targets of the regulatory activities of such regulating polypeptides. More specifically, the invention provides a new method for identifying regulatory dependencies between biochemical species in a cell. In particular embodiments, provided are computer-implemented methods for identifying a regulatory interaction between a transcription factor and a gene target of the transcription factor, or between a transcription factor and a set of gene targets of the transcription factor. Further provided are genome-scale methods for predicting regulatory interactions between a set of transcription factors and a corresponding set of transcriptional target substrates thereof.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2012},
month = {11}
}
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