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Title: Methods of treating Parkinson's disease using viral vectors

Abstract

Methods of delivering viral vectors, particularly recombinant AAV virions, to the central nervous system (CNS) are provided for the treatment of CNS disorders, particularly those disorders which involve the neurotransmitter dopamine. The methods entail providing rAAV virions that comprise a transgene encoding aromatic amino acid decarboxylase (AADC) and administering the virions to the brain of a mammal using a non-manual pump.

Inventors:
;
Issue Date:
Research Org.:
Univ. of California, Oakland, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1080363
Patent Number(s):
8309355
Application Number:
12/384,935
Assignee:
Genzyme Corporation (Framingham, MA); The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
DOE Contract Number:  
AC02-05CH11231
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Bankiewicz, Krys, and Cunningham, Janet. Methods of treating Parkinson's disease using viral vectors. United States: N. p., 2012. Web.
Bankiewicz, Krys, & Cunningham, Janet. Methods of treating Parkinson's disease using viral vectors. United States.
Bankiewicz, Krys, and Cunningham, Janet. Tue . "Methods of treating Parkinson's disease using viral vectors". United States. https://www.osti.gov/servlets/purl/1080363.
@article{osti_1080363,
title = {Methods of treating Parkinson's disease using viral vectors},
author = {Bankiewicz, Krys and Cunningham, Janet},
abstractNote = {Methods of delivering viral vectors, particularly recombinant AAV virions, to the central nervous system (CNS) are provided for the treatment of CNS disorders, particularly those disorders which involve the neurotransmitter dopamine. The methods entail providing rAAV virions that comprise a transgene encoding aromatic amino acid decarboxylase (AADC) and administering the virions to the brain of a mammal using a non-manual pump.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2012},
month = {11}
}

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Works referenced in this record:

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