In vivo spectral micro-imaging of tissue
Abstract
In vivo endoscopic methods an apparatuses for implementation of fluorescence and autofluorescence microscopy, with and without the use of exogenous agents, effectively (with resolution sufficient to image nuclei) visualize and categorize various abnormal tissue forms.
- Inventors:
- Issue Date:
- Research Org.:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1080282
- Patent Number(s):
- 8320650
- Application Number:
- 12/615,085
- Assignee:
- Lawrence Livermore National Security, LLC (Livermore, CA); The Regents of the University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- DOE Contract Number:
- AC52-07NA27344
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES
Citation Formats
Demos, Stavros G, Urayama, Shiro, Lin, Bevin, Saroufeem, Ramez, and Ghobrial, Moussa. In vivo spectral micro-imaging of tissue. United States: N. p., 2012.
Web.
Demos, Stavros G, Urayama, Shiro, Lin, Bevin, Saroufeem, Ramez, & Ghobrial, Moussa. In vivo spectral micro-imaging of tissue. United States.
Demos, Stavros G, Urayama, Shiro, Lin, Bevin, Saroufeem, Ramez, and Ghobrial, Moussa. Tue .
"In vivo spectral micro-imaging of tissue". United States. https://www.osti.gov/servlets/purl/1080282.
@article{osti_1080282,
title = {In vivo spectral micro-imaging of tissue},
author = {Demos, Stavros G and Urayama, Shiro and Lin, Bevin and Saroufeem, Ramez and Ghobrial, Moussa},
abstractNote = {In vivo endoscopic methods an apparatuses for implementation of fluorescence and autofluorescence microscopy, with and without the use of exogenous agents, effectively (with resolution sufficient to image nuclei) visualize and categorize various abnormal tissue forms.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2012},
month = {11}
}
Works referenced in this record:
Detection of preinvasive cancer cells
journal, July 2000
- Backman, V.; Wallace, M. B.; Perelman, L. T.
- Nature, Vol. 406, Issue 6791
Laser-induced fluorescence spectroscopy of human colonic mucosa
journal, July 1990
- Kapadia, Cyrus R.; Cutruzzola, Francis W.; O'Brien, Kenneth M.
- Gastroenterology, Vol. 99, Issue 1
Two-photon laser scanning fluorescence microscopy
journal, April 1990
- Denk, W.; Strickler, J.; Webb, W.
- Science, Vol. 248, Issue 4951
Confocal Examination of Nonmelanoma Cancers in Thick Skin Excisions to Potentially Guide Mohs Micrographic Surgery Without Frozen Histopathology
journal, November 2001
- Rajadhyaksha, Milind; Menaker, Gregg; Flotte, Thomas
- Journal of Investigative Dermatology, Vol. 117, Issue 5
Laser-induced autofluorescence microscopy of normal and tumor human colonic tissue
journal, January 2004
- Huang, Zhiwei; Zheng, Wei; Xie, Shusen
- International Journal of Oncology
Second-harmonic imaging in the scanning optical microscope
journal, September 1978
- Gannaway, J. N.; Sheppard, C. J. R.
- Optical and Quantum Electronics, Vol. 10, Issue 5
Three-Dimensional Vibrational Imaging by Coherent Anti-Stokes Raman Scattering
journal, May 1999
- Zumbusch, Andreas; Holtom, Gary R.; Xie, X. Sunney
- Physical Review Letters, Vol. 82, Issue 20
Hyperspectral imaging of cells: toward real-time pathological assessment
conference, December 2003
- Demos, Stavros G.; Ramsamooj, Rajen
- Optical Science and Technology, SPIE's 48th Annual Meeting, SPIE Proceedings
Laser induced fluorescence spectroscopy from native cancerous and normal tissue
journal, December 1984
- Alfano, R.; Tata, D.; Cordero, J.
- IEEE Journal of Quantum Electronics, Vol. 20, Issue 12, p. 1507-1511
Quantitative laser scanning confocal autofluorescence microscopy of normal, premalignant, and malignant colonic tissues
journal, October 1999
- Wang, Hsing-Wen; Willis, J.; Canto, M. J. F.
- IEEE Transactions on Biomedical Engineering, Vol. 46, Issue 10, p. 1246-1252
Spectroscopic Diagnosis Of Colonic Dysplasia
journal, June 1991
- Richards-Kortum, R.; Rava, R. P.; Petras, R. E.
- Photochemistry and Photobiology, Vol. 53, Issue 6, p. 777-786
Characterization of human breast biopsy specimens with near-IR Raman spectroscopy
journal, February 1994
- Frank, Christopher J.; Redd, Douglas C. B.; Gansler, Ted S.
- Analytical Chemistry, Vol. 66, Issue 3
Cervical Precancer Detection Using a Multivariate Statistical Algorithm Based on Laser-Induced Fluorescence Spectra at Multiple Excitation Wavelengths
journal, October 1996
- Ramanujam, Nirmala; Mitchell, Michele Follen; Mahadevan-Jansen, Anita
- Photochemistry and Photobiology, Vol. 64, Issue 4