Microchip capillary electrophoresis absent electrokinetic injection
Abstract
Microchip capillary electrophoresis (CE) utilizing a sample injector based on a mechanical valve rather than electrokinetic injection can provide improved sample injections, enhanced capabilities, and can eliminate the need for changing the electric field in the separation channel to induce sample injection. In one instance CE electrodes continuously apply an electric field for CE separation along a separation channel. A sample channel is connected to the separation channel at an intersection and has a sample pressure that is greater than that which is present in the separation channel near the intersection. The sample channel does not have electrodes that apply voltages for electrokinetic injection. A sample injector in the sample channel or at the intersection comprises a mechanical valve to control sample injection from the sample channel to the separation channel.
- Inventors:
- Issue Date:
- Research Org.:
- Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1079404
- Patent Number(s):
- 8277659
- Application Number:
- 12/889,108
- Assignee:
- Battelle Memorial Institute (Richland, WA)
- Patent Classifications (CPCs):
-
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- DOE Contract Number:
- AC05-76RL01830
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2010 Sep 23
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Sun, Xuefei, Kelly, Ryan T., Tang, Keqi, and Smith, Richard D. Microchip capillary electrophoresis absent electrokinetic injection. United States: N. p., 2012.
Web.
Sun, Xuefei, Kelly, Ryan T., Tang, Keqi, & Smith, Richard D. Microchip capillary electrophoresis absent electrokinetic injection. United States.
Sun, Xuefei, Kelly, Ryan T., Tang, Keqi, and Smith, Richard D. Tue .
"Microchip capillary electrophoresis absent electrokinetic injection". United States. https://www.osti.gov/servlets/purl/1079404.
@article{osti_1079404,
title = {Microchip capillary electrophoresis absent electrokinetic injection},
author = {Sun, Xuefei and Kelly, Ryan T. and Tang, Keqi and Smith, Richard D.},
abstractNote = {Microchip capillary electrophoresis (CE) utilizing a sample injector based on a mechanical valve rather than electrokinetic injection can provide improved sample injections, enhanced capabilities, and can eliminate the need for changing the electric field in the separation channel to induce sample injection. In one instance CE electrodes continuously apply an electric field for CE separation along a separation channel. A sample channel is connected to the separation channel at an intersection and has a sample pressure that is greater than that which is present in the separation channel near the intersection. The sample channel does not have electrodes that apply voltages for electrokinetic injection. A sample injector in the sample channel or at the intersection comprises a mechanical valve to control sample injection from the sample channel to the separation channel.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Oct 02 00:00:00 EDT 2012},
month = {Tue Oct 02 00:00:00 EDT 2012}
}
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