Methods of treating ovarian cancer by modulating SnoN

Nanjundan, Meere; Mills, Gordon; Smith, Dawn

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Title: Methods of treating ovarian cancer by modulating SnoN

Inventors:: Nanjundan, Meere; Mills, Gordon; Smith, Dawn

Issue Date:: Tue Jul 03 00:00:00 EDT 2012

Research Org.:: University of South Florida (Tampa, FL)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1078515

Patent Number(s):: 8211646

Application Number:: 12/619,345

Assignee:: University of South Florida (Tampa, FL)

Patent Classifications (CPCs):: C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS

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C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C12N15/1135 - {against oncogenes or tumor suppressor genes}
C12N2310/14 - interfering N.A.

C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
C12Q1/6886 - for cancer
C12Q2600/158 - Expression markers
C12Q2600/178 - miRNA, siRNA or ncRNA

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DOE Contract Number:: AC03-76SF00098

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES

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                    Nanjundan, Meere, Mills, Gordon, and Smith, Dawn. Methods of treating ovarian cancer by modulating SnoN.  United States: N. p., 2012. 
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                    Nanjundan, Meere, Mills, Gordon, & Smith, Dawn. Methods of treating ovarian cancer by modulating SnoN.  United States.

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                    Nanjundan, Meere, Mills, Gordon, and Smith, Dawn. Tue .  
        "Methods of treating ovarian cancer by modulating SnoN".  United States.  https://www.osti.gov/servlets/purl/1078515.

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@article{osti_1078515,

  title        = {Methods of treating ovarian cancer by modulating SnoN},

  author       = {Nanjundan, Meere and Mills, Gordon and Smith, Dawn},

  abstractNote = {},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Jul 03 00:00:00 EDT 2012},

  month        = {Tue Jul 03 00:00:00 EDT 2012}

}

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Patent Gray, Joe W.; Guan, Yinghui; Kuo, Wen-Lin; ...

Cancer markers may be developed to detect diseases characterized by increased expression of apoptosis-suppressing genes, such as aggressive cancers. Genes in the human chromosomal regions, 8q24, 11q13, 20q11-q13, were found to be amplified indicating in vivo drug resistance in diseases such as ovarian cancer. Diagnosis and assessment of amplification levels certain genes shown to be amplified, including PVT1, can be useful in prediction of poor outcome of patient's response and drug resistance in ovarian cancer patients with low survival rates. Certain genes were found to be high priority therapeutic targets by the identification of recurrent aberrations involving genome sequence, copymore » « less
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Patent Moonlee, Sun-Young; Bissell, Mina J.; Furuta, Saori; ...

The application describes therapeutic compositions and methods for treating cancer. For example, therapeutic compositions and methods related to inhibition of FAM83A (family with sequence similarity 83) are provided. The application also describes methods for diagnosing cancer resistance to EGFR inhibitors. For example, a method of diagnosing cancer resistance to EGFR inhibitors by detecting increased FAM83A levels is described.
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Patent Wilson, Aaron D.; Wendt, Daniel S.; Orme, Christopher J.; ...

A method of treating a switchable polarity material comprises introducing a first feed stream comprising a solvent and a non-polar form of the switchable polarity material to a first side of a gas diffusion membrane. A second feed stream comprising an acid gas is introduced to a second side of the gas diffusion membrane opposing the first side of the gas diffusion membrane. Molecules of the acid gas of the second feed stream are diffused across the gas diffusion membrane and into the first feed stream to form a product stream comprising a polar form of the switchable polarity material.more » « less
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Patent Wertsching, Alan K [Idaho Falls, ID]; Peterson, Eric S [Idaho Falls, ID]; Wey, John E [Idaho Falls, ID]

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Title: Methods of treating ovarian cancer by modulating SnoN

Citation Formats

Inability of Transforming Growth Factor-β to Cause SnoN Degradation Leads to Resistance to Transforming Growth Factor-β–Induced Growth Arrest in Esophageal Cancer Cells journal, June 2005

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? journal, May 2009

Mutation analysis of the Smad3 gene in human ovarian cancers. journal, November 1999

Crystal Structure of the Dachshund Homology Domain of Human SKI journal, May 2004

Autophagic cell death unraveled: Pharmacological inhibition of apoptosis and autophagy enables necrosis journal, May 2008

Targeted Degradation of the AML1/MDS1/EVI1 Oncoprotein by Arsenic Trioxide journal, November 2006

TAK1 MAPK Kinase Kinase Mediates Transforming Growth Factor-β Signaling by Targeting SnoN Oncoprotein for Degradation journal, February 2007

Extracellular heat shock protein 90: A role for a molecular chaperone in cell motility and cancer metastasis journal, October 2007

Smurf2 up-regulation activates telomere-dependent senescence journal, December 2004

Evi-1 ZF1 DNA binding activity and a second distinct transcriptional repressor region are both required for optimal transformation of Rat1 fibroblasts journal, April 1998

Expression Profiling Identifies Altered Expression of Genes That Contribute to the Inhibition of Transforming Growth Factor-β Signaling in Ovarian Cancer journal, September 2006

Requirement for the SnoN Oncoprotein in Transforming Growth Factor β-Induced Oncogenic Transformation of Fibroblast Cells journal, December 2005

Protein kinase C isoform expression in ovarian carcinoma correlates with indicators of poor prognosis journal, September 2003

Comparative genomic hybridization reveals DNA copy number gains to frequently occur in human prostate cancer journal, May 1999

Arsenic Trioxide inhibits the growth of human ovarian carcinoma cell line journal, December 2005

Glutathione depletion overcomes resistance to arsenic trioxide in arsenic-resistant cell lines journal, May 2003

Ski/Sno and TGF-β signaling journal, March 2001

Arsenic trioxide reduces the invasive and metastatic properties of nasopharyngeal carcinoma cells in vitro journal, May 2006

Critical regulation of TGF signaling by Hsp90 journal, June 2008

Investigations for Fine Mapping of Amplifications in Chromosome 3q26.3–28 Frequently Occurring in Squamous Cell Carcinomas of the Head and Neck journal, January 2002

Synergism between Arsenic Trioxide and Heat Shock Protein 90 Inhibitors on Signal Transducer and Activator of Transcription Protein 3 Activity--Pharmacodynamic Drug-Drug Interaction Modeling journal, April 2007

Akt interacts directly with Smad3 to regulate the sensitivity to TGF-β-induced apoptosis journal, March 2004

Identification of Binding Sites of EVI1 in Mammalian Cells journal, July 2005

Inhibition of macroautophagy by bafilomycin A1 lowers proliferation and induces apoptosis in colon cancer cells journal, May 2009

BRAFE600-associated senescence-like cell cycle arrest of human naevi journal, August 2005

Inhibitory role of TGIF in the As2O3-regulated p21 WAF1/CIP1 expression journal, January 2008

In search of an “autophagomometer” journal, July 2009

Superoxide is the major reactive oxygen species regulating autophagy journal, May 2009

HSP27 and HSP70: Potentially Oncogenic Apoptosis Inhibitors journal, November 2003

Genetic dissection of the role of p21Cip1/Waf1 in p53-mediated tumour suppression journal, September 2006

Markers of senescence? journal, January 2002

Pharmacologic inhibitors of PI3K/Akt potentiate the apoptotic action of the antileukemic drug arsenic trioxide via glutathione depletion and increased peroxide accumulation in myeloid leukemia cells journal, May 2005

Arsenic trioxide, a therapeutic agent for APL journal, October 2001

Oncogene-Induced Senescence: Putting the Brakes on Tumor Development: Figure 1. journal, March 2006

Arkadia Activates Smad3/Smad4-Dependent Transcription by Triggering Signal-Induced SnoN Degradation journal, June 2007

Negative Feedback Regulation of TGF- Signaling by the SnoN Oncoprotein journal, October 1999

Assembly of microarrays for genome-wide measurement of DNA copy number journal, October 2001

SnoN Is a Cell Type-specific Mediator of Transforming Growth Factor-β Responses journal, January 2005

Arsenic trioxide induces apoptosis in cisplatin-sensitive and -resistant ovarian cancer cell lines journal, September 2005

Proteasomal activity modulates TGF-ß signaling in a gene-specific manner journal, August 2002

The sno gene, which encodes a component of the histone deacetylase complex, acts as a tumor suppressor in mice journal, May 2000

Molecular alterations of theAKT2 oncogene in ovarian and breast carcinomas journal, August 1995

Novel amplification unit at chromosome 3q25-q27 in human prostate cancer journal, January 2000

Arsenic trioxide is highly cytotoxic to small cell lung carcinoma cells journal, January 2009

Arsenic trioxide induced the apoptosis of laryngeal cancer via down-regulation of survivin mRNA journal, March 2008

Amplification of SKI Is a Prognostic Marker in Early Colorectal Cancer journal, May 2004

Expression of active plasminogen activator inhibitor-1 reduces cell migration and invasion in breast and gynecological cancer cells journal, June 2004

Sumoylated SnoN Represses Transcription in a Promoter-specific Manner journal, September 2006

PML nuclear bodies: dynamic sensors of DNA damage and cellular stress journal, January 2004

Arsenic trioxide (As2O3) inhibits invasion of HT1080 human fibrosarcoma cells: Role of nuclear factor-κB and reactive oxygen species journal, January 2005

The MRP1-Mediated Effluxes of Arsenic and Antimony Do Not Require Arsenic–Glutathione and Antimony–Glutathione Complex Formation journal, April 2002

Increased expression of c-Ski as a co-repressor in transforming growth factor-? signaling correlates with progression of esophageal squamous cell carcinoma journal, January 2004

Prognostic significance of urokinase (uPA) and its inhibitor PAI-1 for survival in advanced ovarian carcinoma stage FIGO IIIc journal, March 1999

Role of PI3K and AKT specific isoforms in ovarian cancer cell migration, invasion and proliferation through the p70S6K1 pathway journal, December 2006

Intergenic splicing of MDS1 and EVI1 occurs in normal tissues as well as in myeloid leukemia and produces a new member of the PR domain family. journal, February 1996

SKI pathways inducing progression of human melanoma journal, June 2005

Effect of autophagy on multiple myeloma cell viability journal, June 2009

Arkadia Induces Degradation of SnoN and c-Ski to Enhance Transforming Growth Factor-β Signaling journal, May 2007

PIK3CA is implicated as an oncogene in ovarian cancer journal, January 1999

Overexpression of SnoN/SkiL, amplified at the 3q26.2 locus, in ovarian cancers: A role in ovarian pathogenesis journal, May 2008

The Transforming Activity of Ski and SnoN Is Dependent on Their Ability to Repress the Activity of Smad Proteins journal, May 2003

Oxidation as a Post-Translational Modification that Regulates Autophagy journal, July 2007

SUMO: a regulator of gene expression and genome integrity journal, March 2004

Increased susceptibility to tumorigenesis of ski-deficient heterozygous mice journal, December 2001

Transforming growth factor-beta inhibits proliferation of human ovarian cancer cells obtained from ascites journal, July 1994

Arsenic trioxide inhibits proliferation in K562 cells by changing cell cycle and survivin expression journal, August 2004

Arsenic trioxide (As2O3) inhibits peritoneal invasion of ovarian carcinoma cells in vitro and in vivo journal, October 2006

Breast cancer in young women (?35 years): Genomic aberrations detected by comparative genomic hybridization journal, September 2003

Targeting Hsp90 by 17-AAG in leukemia cells: mechanisms for synergistic and antagonistic drug combinations with arsenic trioxide and Ara-C journal, February 2006

Inability of Transforming Growth Factor-β to Cause SnoN Degradation Leads to Resistance to Transforming Growth Factor-β–Induced Growth Arrest in Esophageal Cancer Cells
journal, June 2005

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
journal, May 2009

Mutation analysis of the Smad3 gene in human ovarian cancers.
journal, November 1999

Crystal Structure of the Dachshund Homology Domain of Human SKI
journal, May 2004

Autophagic cell death unraveled: Pharmacological inhibition of apoptosis and autophagy enables necrosis
journal, May 2008

Targeted Degradation of the AML1/MDS1/EVI1 Oncoprotein by Arsenic Trioxide
journal, November 2006

TAK1 MAPK Kinase Kinase Mediates Transforming Growth Factor-β Signaling by Targeting SnoN Oncoprotein for Degradation
journal, February 2007

Extracellular heat shock protein 90: A role for a molecular chaperone in cell motility and cancer metastasis
journal, October 2007

Smurf2 up-regulation activates telomere-dependent senescence
journal, December 2004

Evi-1 ZF1 DNA binding activity and a second distinct transcriptional repressor region are both required for optimal transformation of Rat1 fibroblasts
journal, April 1998

Expression Profiling Identifies Altered Expression of Genes That Contribute to the Inhibition of Transforming Growth Factor-β Signaling in Ovarian Cancer
journal, September 2006

Requirement for the SnoN Oncoprotein in Transforming Growth Factor β-Induced Oncogenic Transformation of Fibroblast Cells
journal, December 2005

Protein kinase C isoform expression in ovarian carcinoma correlates with indicators of poor prognosis
journal, September 2003

Comparative genomic hybridization reveals DNA copy number gains to frequently occur in human prostate cancer
journal, May 1999

Arsenic Trioxide inhibits the growth of human ovarian carcinoma cell line
journal, December 2005

Glutathione depletion overcomes resistance to arsenic trioxide in arsenic-resistant cell lines
journal, May 2003

Ski/Sno and TGF-β signaling
journal, March 2001

Arsenic trioxide reduces the invasive and metastatic properties of nasopharyngeal carcinoma cells in vitro
journal, May 2006

Critical regulation of TGF signaling by Hsp90
journal, June 2008

Investigations for Fine Mapping of Amplifications in Chromosome 3q26.3–28 Frequently Occurring in Squamous Cell Carcinomas of the Head and Neck
journal, January 2002

Synergism between Arsenic Trioxide and Heat Shock Protein 90 Inhibitors on Signal Transducer and Activator of Transcription Protein 3 Activity--Pharmacodynamic Drug-Drug Interaction Modeling
journal, April 2007

Akt interacts directly with Smad3 to regulate the sensitivity to TGF-β-induced apoptosis
journal, March 2004

Identification of Binding Sites of EVI1 in Mammalian Cells
journal, July 2005

Inhibition of macroautophagy by bafilomycin A1 lowers proliferation and induces apoptosis in colon cancer cells
journal, May 2009

BRAFE600-associated senescence-like cell cycle arrest of human naevi
journal, August 2005

Inhibitory role of TGIF in the As2O3-regulated p21 WAF1/CIP1 expression
journal, January 2008

In search of an “autophagomometer”
journal, July 2009

Superoxide is the major reactive oxygen species regulating autophagy
journal, May 2009

HSP27 and HSP70: Potentially Oncogenic Apoptosis Inhibitors
journal, November 2003

Genetic dissection of the role of p21Cip1/Waf1 in p53-mediated tumour suppression
journal, September 2006

Markers of senescence?
journal, January 2002

Pharmacologic inhibitors of PI3K/Akt potentiate the apoptotic action of the antileukemic drug arsenic trioxide via glutathione depletion and increased peroxide accumulation in myeloid leukemia cells
journal, May 2005

Arsenic trioxide, a therapeutic agent for APL
journal, October 2001

Oncogene-Induced Senescence: Putting the Brakes on Tumor Development: Figure 1.
journal, March 2006

Arkadia Activates Smad3/Smad4-Dependent Transcription by Triggering Signal-Induced SnoN Degradation
journal, June 2007

Negative Feedback Regulation of TGF- Signaling by the SnoN Oncoprotein
journal, October 1999

Assembly of microarrays for genome-wide measurement of DNA copy number
journal, October 2001

SnoN Is a Cell Type-specific Mediator of Transforming Growth Factor-β Responses
journal, January 2005

Arsenic trioxide induces apoptosis in cisplatin-sensitive and -resistant ovarian cancer cell lines
journal, September 2005

Proteasomal activity modulates TGF-ß signaling in a gene-specific manner
journal, August 2002

The sno gene, which encodes a component of the histone deacetylase complex, acts as a tumor suppressor in mice
journal, May 2000

Molecular alterations of theAKT2 oncogene in ovarian and breast carcinomas
journal, August 1995

Novel amplification unit at chromosome 3q25-q27 in human prostate cancer
journal, January 2000

Arsenic trioxide is highly cytotoxic to small cell lung carcinoma cells
journal, January 2009

Arsenic trioxide induced the apoptosis of laryngeal cancer via down-regulation of survivin mRNA
journal, March 2008

Amplification of SKI Is a Prognostic Marker in Early Colorectal Cancer
journal, May 2004

Expression of active plasminogen activator inhibitor-1 reduces cell migration and invasion in breast and gynecological cancer cells
journal, June 2004

Sumoylated SnoN Represses Transcription in a Promoter-specific Manner
journal, September 2006

PML nuclear bodies: dynamic sensors of DNA damage and cellular stress
journal, January 2004

Arsenic trioxide (As2O3) inhibits invasion of HT1080 human fibrosarcoma cells: Role of nuclear factor-κB and reactive oxygen species
journal, January 2005

The MRP1-Mediated Effluxes of Arsenic and Antimony Do Not Require Arsenic–Glutathione and Antimony–Glutathione Complex Formation
journal, April 2002

Increased expression of c-Ski as a co-repressor in transforming growth factor-? signaling correlates with progression of esophageal squamous cell carcinoma
journal, January 2004

Prognostic significance of urokinase (uPA) and its inhibitor PAI-1 for survival in advanced ovarian carcinoma stage FIGO IIIc
journal, March 1999

Role of PI3K and AKT specific isoforms in ovarian cancer cell migration, invasion and proliferation through the p70S6K1 pathway
journal, December 2006

Intergenic splicing of MDS1 and EVI1 occurs in normal tissues as well as in myeloid leukemia and produces a new member of the PR domain family.
journal, February 1996

SKI pathways inducing progression of human melanoma
journal, June 2005

Effect of autophagy on multiple myeloma cell viability
journal, June 2009

Arkadia Induces Degradation of SnoN and c-Ski to Enhance Transforming Growth Factor-β Signaling
journal, May 2007

PIK3CA is implicated as an oncogene in ovarian cancer
journal, January 1999

Overexpression of SnoN/SkiL, amplified at the 3q26.2 locus, in ovarian cancers: A role in ovarian pathogenesis
journal, May 2008

The Transforming Activity of Ski and SnoN Is Dependent on Their Ability to Repress the Activity of Smad Proteins
journal, May 2003

Oxidation as a Post-Translational Modification that Regulates Autophagy
journal, July 2007

SUMO: a regulator of gene expression and genome integrity
journal, March 2004

Increased susceptibility to tumorigenesis of ski-deficient heterozygous mice
journal, December 2001

Transforming growth factor-beta inhibits proliferation of human ovarian cancer cells obtained from ascites
journal, July 1994

Arsenic trioxide inhibits proliferation in K562 cells by changing cell cycle and survivin expression
journal, August 2004

Arsenic trioxide (As2O3) inhibits peritoneal invasion of ovarian carcinoma cells in vitro and in vivo
journal, October 2006

Breast cancer in young women (?35 years): Genomic aberrations detected by comparative genomic hybridization
journal, September 2003

Targeting Hsp90 by 17-AAG in leukemia cells: mechanisms for synergistic and antagonistic drug combinations with arsenic trioxide and Ara-C
journal, February 2006