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Title: Amphiphiles for protein solubilization and stabilization

Abstract

The invention provides amphiphiles for manipulating membrane proteins. The amphiphiles can feature carbohydrate-derived hydrophilic groups and branchpoints in the hydrophilic moiety and/or in a lipophilic moiety. Such amphiphiles are useful as detergents for solubilization and stabilization of membrane proteins, including photosynthetic protein superassemblies obtained from bacterial membranes.

Inventors:
; ; ;
Issue Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1078330
Patent Number(s):
8263754
Application Number:
12/420,701
Assignee:
Wisconsin Alumni Research Foundation (Madison, WI) ; UChicago Argonne, LLC (Chicago, IL)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07H - SUGARS
DOE Contract Number:  
AC02-06CH11357; W-31-109-ENG-38
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Gellman, Samuel Helmer, Chae, Pil Seok, Laible, Philip D., and Wander, Marc J. Amphiphiles for protein solubilization and stabilization. United States: N. p., 2012. Web.
Gellman, Samuel Helmer, Chae, Pil Seok, Laible, Philip D., & Wander, Marc J. Amphiphiles for protein solubilization and stabilization. United States.
Gellman, Samuel Helmer, Chae, Pil Seok, Laible, Philip D., and Wander, Marc J. Tue . "Amphiphiles for protein solubilization and stabilization". United States. https://www.osti.gov/servlets/purl/1078330.
@article{osti_1078330,
title = {Amphiphiles for protein solubilization and stabilization},
author = {Gellman, Samuel Helmer and Chae, Pil Seok and Laible, Philip D. and Wander, Marc J.},
abstractNote = {The invention provides amphiphiles for manipulating membrane proteins. The amphiphiles can feature carbohydrate-derived hydrophilic groups and branchpoints in the hydrophilic moiety and/or in a lipophilic moiety. Such amphiphiles are useful as detergents for solubilization and stabilization of membrane proteins, including photosynthetic protein superassemblies obtained from bacterial membranes.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2012},
month = {9}
}

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Works referenced in this record:

Synthesis of some aglycon analogs of globotriosylceramide
journal, December 1999


Synthesis and mesogenic properties of a Y-shaped glyco-glycero-lipid
journal, August 2004