Amphiphiles for protein solubilization and stabilization
Abstract
The invention provides amphiphiles for manipulating membrane proteins. The amphiphiles can feature carbohydrate-derived hydrophilic groups and branchpoints in the hydrophilic moiety and/or in a lipophilic moiety. Such amphiphiles are useful as detergents for solubilization and stabilization of membrane proteins, including photosynthetic protein superassemblies obtained from bacterial membranes.
- Inventors:
- Issue Date:
- Research Org.:
- Argonne National Laboratory (ANL), Argonne, IL (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1078330
- Patent Number(s):
- 8263754
- Application Number:
- 12/420,701
- Assignee:
- Wisconsin Alumni Research Foundation (Madison, WI) ; UChicago Argonne, LLC (Chicago, IL)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07H - SUGARS
- DOE Contract Number:
- AC02-06CH11357; W-31-109-ENG-38
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Gellman, Samuel Helmer, Chae, Pil Seok, Laible, Philip D., and Wander, Marc J. Amphiphiles for protein solubilization and stabilization. United States: N. p., 2012.
Web.
Gellman, Samuel Helmer, Chae, Pil Seok, Laible, Philip D., & Wander, Marc J. Amphiphiles for protein solubilization and stabilization. United States.
Gellman, Samuel Helmer, Chae, Pil Seok, Laible, Philip D., and Wander, Marc J. Tue .
"Amphiphiles for protein solubilization and stabilization". United States. https://www.osti.gov/servlets/purl/1078330.
@article{osti_1078330,
title = {Amphiphiles for protein solubilization and stabilization},
author = {Gellman, Samuel Helmer and Chae, Pil Seok and Laible, Philip D. and Wander, Marc J.},
abstractNote = {The invention provides amphiphiles for manipulating membrane proteins. The amphiphiles can feature carbohydrate-derived hydrophilic groups and branchpoints in the hydrophilic moiety and/or in a lipophilic moiety. Such amphiphiles are useful as detergents for solubilization and stabilization of membrane proteins, including photosynthetic protein superassemblies obtained from bacterial membranes.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Sep 11 00:00:00 EDT 2012},
month = {Tue Sep 11 00:00:00 EDT 2012}
}
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Works referenced in this record:
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