Method to improve cancerous lesion detection sensitivity in a dedicated dual-head scintimammography system

Kieper, Douglas Arthur; Majewski, Stanislaw; Welch, Benjamin L

Title: Method to improve cancerous lesion detection sensitivity in a dedicated dual-head scintimammography system

Abstract

An improved method for enhancing the contrast between background and lesion areas of a breast undergoing dual-head scintimammographic examination comprising: 1) acquiring a pair of digital images from a pair of small FOV or mini gamma cameras compressing the breast under examination from opposing sides; 2) inverting one of the pair of images to align or co-register with the other of the images to obtain co-registered pixel values; 3) normalizing the pair of images pixel-by-pixel by dividing pixel values from each of the two acquired images and the co-registered image by the average count per pixel in the entire breast area of the corresponding detector; and 4) multiplying the number of counts in each pixel by the value obtained in step 3 to produce a normalization enhanced two dimensional contrast map. This enhanced (increased contrast) contrast map enhances the visibility of minor local increases (uptakes) of activity over the background and therefore improves lesion detection sensitivity, especially of small lesions.

Inventors:

Kieper, Douglas Arthur ^[1]; Majewski, Stanislaw ^[2]; Welch, Benjamin L ^[3]

Seattle, WA
Morgantown, WV
Hampton, VA

Issue Date:: 2012-07-03

Research Org.:: Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1069109

Patent Number(s):: RE43,499

Application Number:: 12/913,372

Assignee:: Jefferson Science Associates, LLC (Newport News, VA)

DOE Contract Number:: AC05-84ER40150

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES

Citation Formats


                    Kieper, Douglas Arthur, Majewski, Stanislaw, and Welch, Benjamin L. Method to improve cancerous lesion detection sensitivity in a dedicated dual-head scintimammography system.  United States: N. p., 2012. 
        Web.

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                    Kieper, Douglas Arthur, Majewski, Stanislaw, & Welch, Benjamin L. Method to improve cancerous lesion detection sensitivity in a dedicated dual-head scintimammography system.  United States.

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                    Kieper, Douglas Arthur, Majewski, Stanislaw, and Welch, Benjamin L. Tue .  
        "Method to improve cancerous lesion detection sensitivity in a dedicated dual-head scintimammography system".  United States.  https://www.osti.gov/servlets/purl/1069109.

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@article{osti_1069109,

  title        = {Method to improve cancerous lesion detection sensitivity in a dedicated dual-head scintimammography system},

  author       = {Kieper, Douglas Arthur and Majewski, Stanislaw and Welch, Benjamin L},

  abstractNote = {An improved method for enhancing the contrast between background and lesion areas of a breast undergoing dual-head scintimammographic examination comprising: 1) acquiring a pair of digital images from a pair of small FOV or mini gamma cameras compressing the breast under examination from opposing sides; 2) inverting one of the pair of images to align or co-register with the other of the images to obtain co-registered pixel values; 3) normalizing the pair of images pixel-by-pixel by dividing pixel values from each of the two acquired images and the co-registered image by the average count per pixel in the entire breast area of the corresponding detector; and 4) multiplying the number of counts in each pixel by the value obtained in step 3 to produce a normalization enhanced two dimensional contrast map. This enhanced (increased contrast) contrast map enhances the visibility of minor local increases (uptakes) of activity over the background and therefore improves lesion detection sensitivity, especially of small lesions.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2012},

  month        = {7}

}

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Works referenced in this record:

Optimization of breast imaging procedure with dedicated compact gamma cameras
journal, January 2003

Kieper, D.; Majewski, S.; Kross, B.
Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Vol. 497, Issue 1
https://doi.org/10.1016/S0168-9002(02)01907-1

Improved lesion visibility in a dedicated dual head scintimammography system - phantom results
conference, January 2003

Kieper, D.; Majewski, S.; Goodale, P.
2002 IEEE Nuclear Science Symposium Conference Record
https://doi.org/10.1109/NSSMIC.2002.1239568

Optimization of dedicated scintimammography procedure using detector prototypes and compressible phantoms
journal, June 2001

Majewski, S.; Kieper, D.; Curran, E.
IEEE Transactions on Nuclear Science, Vol. 48, Issue 3
https://doi.org/10.1109/23.940170

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Title: Method to improve cancerous lesion detection sensitivity in a dedicated dual-head scintimammography system

Abstract

Citation Formats

Optimization of breast imaging procedure with dedicated compact gamma cameras journal, January 2003

Improved lesion visibility in a dedicated dual head scintimammography system - phantom results conference, January 2003

Optimization of dedicated scintimammography procedure using detector prototypes and compressible phantoms journal, June 2001

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journal, January 2003

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journal, June 2001