DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: FGF growth factor analogs

Abstract

The present invention provides a fibroblast growth factor heparin-binding analog of the formula: ##STR00001## where R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, X, Y and Z are as defined, pharmaceutical compositions, coating compositions and medical devices including the fibroblast growth factor heparin-binding analog of the foregoing formula, and methods and uses thereof.

Inventors:
 [1];  [2];  [3];  [4]
  1. Gaithersburg, MD
  2. Poquott, NY
  3. Plainview, NY
  4. Germantown, MD
Issue Date:
Research Org.:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1067339
Patent Number(s):
8227411
Application Number:
Assignee:
BioSurface Engineering Technologies, Incle (Rockvile, MD); Brookhaven and Science Associates (Upton, NY)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
DOE Contract Number:  
AC02-98CH10886.
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Zamora, Paul O, Pena, Louis A, Lin, Xinhua, and Takahashi, Kazuyuki. FGF growth factor analogs. United States: N. p., 2012. Web.
Zamora, Paul O, Pena, Louis A, Lin, Xinhua, & Takahashi, Kazuyuki. FGF growth factor analogs. United States.
Zamora, Paul O, Pena, Louis A, Lin, Xinhua, and Takahashi, Kazuyuki. Tue . "FGF growth factor analogs". United States. https://www.osti.gov/servlets/purl/1067339.
@article{osti_1067339,
title = {FGF growth factor analogs},
author = {Zamora, Paul O and Pena, Louis A and Lin, Xinhua and Takahashi, Kazuyuki},
abstractNote = {The present invention provides a fibroblast growth factor heparin-binding analog of the formula: ##STR00001## where R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, X, Y and Z are as defined, pharmaceutical compositions, coating compositions and medical devices including the fibroblast growth factor heparin-binding analog of the foregoing formula, and methods and uses thereof.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jul 24 00:00:00 EDT 2012},
month = {Tue Jul 24 00:00:00 EDT 2012}
}

Works referenced in this record:

Trans-repressor activity of nuclear glycosaminoglycans on Fos and Jun/AP-1 oncoprotein-mediated transcription
journal, January 1992


A heparin binding synthetic peptide from human HIP / RPL29 fails to specifically differentiate between anticoagulantly active and inactive species of heparin
journal, February 2003


Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia
journal, May 2001


Enhanced osteogenic promotion around dental implants with synthetic binding motif mimicking bone morphogenetic protein (BMP)-2
journal, January 2006


Identification of a Human Type II Receptor for Bone Morphogenetic Protein-4 That Forms Differential Heteromeric Complexes with Bone Morphogenetic Protein Type I Receptors
journal, September 1995


The challenges of genome sequence annotation or “The devil is in the details”
journal, November 1997


Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox
book, January 1994


Induction of Osteogenic Differentiation by Hedgehog Proteins
journal, August 1997


Engineering of an FGF–proteoglycan fusion protein with heparin-independent, mitogenic activity
journal, June 2000


Amino-terminal sequences of a novel heparin-binding protein from human, bovine, rat, and chick brain: High interspecies homology
journal, April 1990


Multidomain Synthetic Peptide B2A2 Synergistically Enhances BMP-2 In Vitro
journal, November 2004


The Heparin-Binding (Fibroblast) Growth Factor Family of Proteins
journal, June 1989


Fgf-19, a Novel Fibroblast Growth Factor with Unique Specificity for Fgfr4
journal, October 1999


Polymeric system for dual growth factor delivery
journal, November 2001


αvβ3 Integrin Mediates the Cell-adhesive Capacity and Biological Activity of Basic Fibroblast Growth Factor (FGF-2) in Cultured Endothelial Cells
journal, December 1997


A 10-amino acid sequence of fibroblast growth factor 2 is sufficient for its mitogenic activity on neural progenitor cells
journal, June 1997


RGD motif enhances immunogenicity and adjuvanicity of peptide antigens following intranasal immunization
journal, December 2003


Characterization of heparin-binding growth-associated factor receptor on NIH 3T3 cells
journal, January 1992


Genomic structure, mapping, activity and expression of fibroblast growth factor 17
journal, May 1999


Novel Branching Membrane Translocational Peptide as Gene Delivery Vector
journal, November 2002


Receptor- and heparin-binding domains of basic fibroblast growth factor.
journal, April 1988


Appearance of heparin-binding EGF-like growth factor in wound fluid as a response to injury.
journal, May 1993


Structure and Expression of a Novel Fibroblast Growth Factor, FGF-17, Preferentially Expressed in the Embryonic Brain
journal, March 1998


Ear rings: FGF3 involvement comes full circle
journal, August 2000


Overlapping Expression and Redundant Activation of Mesenchymal Fibroblast Growth Factor (FGF) Receptors by Alternatively Spliced FGF-8 Ligands
journal, February 1997


Bone Morphogenetic Protein Receptor Complexes on the Surface of Live Cells: A New Oligomerization Mode for Serine/Threonine Kinase Receptors
journal, March 2000


Structure and Expression of a Novel Member, FGF-16, of the Fibroblast Growth Factor Family
journal, February 1998


Cloning of a Novel Type II Serine/Threonine Kinase Receptor through Interaction with the Type I Transforming Growth Factor-β Receptor
journal, March 1995


Identification of a novel FGF, FGF-21, preferentially expressed in the liver
journal, June 2000


The Spemann Organizer Signal noggin Binds and Inactivates Bone Morphogenetic Protein 4
journal, August 1996


Biosynthesis of human fibroblast growth factor-5.
journal, April 1991


Structural and functional characterization of full-length heparin-binding growth associated molecule.
journal, January 1992


Interleukin 1 regulates heparin-binding growth factor 2 gene expression in vascular smooth muscle cells.
journal, January 1991


Gene Expression During Autograft Lumbar Spine Fusion and the Effect of Bone Morphogenetic Protein 2
journal, January 1998


Adenovirus-mediated transfer of the HST-1 (FGF4) gene induces increased levels of platelet count in vivo.
journal, December 1994


Keratinocyte Growth Factor: A Fibroblast Growth Factor Family Member with Unusual Target Cell Specificity
journal, December 1991


The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors.
journal, August 1988


FGF-18, a Novel Member of the Fibroblast Growth Factor Family, Stimulates Hepatic and Intestinal Proliferation
journal, October 1998


Augmentation of osseous phenotypes in vivo with a synthetic peptide
journal, January 2007


Constitutively Active BMP Type I Receptors Transduce BMP-2 Signals without the Ligand in C2C12 Myoblasts
journal, September 1997


Peptide Synthesis via Fragment Condensation
book, November 1994


Identification of a peptide blocking vascular endothelial growth factor (VEGF)-mediated angiogenesis
journal, April 2000


Influence of BMPs on the Formation of Osteoblastic Lesions in Metastatic Prostate Cancer
journal, August 2005


Cloning and characterization of a human type II receptor for bone morphogenetic proteins.
journal, August 1995


Hydroxyapatite Granule Graft Combined With Recombinant Human Bone Morphogenic Protein-2 for Solid Lumbar Fusion
journal, January 2002


Poly(L-lysine) has different membrane transport and drug-carrier properties when complexed with heparin.
journal, December 1981


Powers and Pitfalls in Sequence Analysis: The 70% Hurdle
journal, April 2000


MADR1, a MAD-Related Protein That Functions in BMP2 Signaling Pathways
journal, May 1996


Errors in genome annotation
journal, April 1999


Cloning and Characterization of a cDNA Encoding a Novel Fibroblast Growth Factor Preferentially Expressed in Human Heart
journal, February 1999


Local Delivery of Basic Fibroblast Growth Factor (bFGF) Using Adsorbed Silyl-heparin, Benzyl-bis(dimethylsilylmethyl)oxycarbamoyl-heparin
journal, September 2002


Evaluation of Carriers of Bone Morphogenetic Protein for Spinal Fusion
journal, January 2001


Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand
journal, March 1999


Design of Peptides with High Affinities for Heparin and Endothelial Cell Proteoglycans
journal, March 2000


Synthesis of Native Proteins by Chemical Ligation
journal, June 2000


Protein annotation: detective work for function prediction
journal, June 1998


Multiple peptide synthesis
journal, April 1995


From genes to protein structure and function: novel applications of computational approaches in the genomic era
journal, January 2000


A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF
journal, February 1991


Growth factor delivery for bone tissue repair: an update
journal, November 2004


Basic fibroblast growth factor and bone induction in rats
journal, January 1993


Synthetic peptide F2A4-K-NS mimics fibroblast growth factor-2 in vitro and is angiogenic in vivo
journal, May 2006


Identification and characterization of a novel member of the fibroblast growth factor family
journal, May 1998


Evolutionary grouping of the transforming growth factor-β superfamily
journal, April 1992


Go hunting in sequence databases but watch out for the traps
journal, October 1996


Mitogenic properties of a new endothelial cell growth factor related to pleiotrophin
journal, October 1991


Smads as transcriptional co-modulators
journal, April 2000


FGF-20, a Novel Neurotrophic Factor, Preferentially Expressed in the Substantia Nigra Pars Compacta of Rat Brain
journal, October 2000


Designing Biomaterials to Direct Biological Responses
journal, June 1999


Additivity of mutational effects in proteins
journal, September 1990


A synthetic, bioactive PDGF mimetic with binding to both α-PDGF and β-PDGF receptors
journal, January 2007


Role of heparan sulfate in fibroblast growth factor signalling: a structural view
journal, September 2001


Bone Morphogenetic Proteins: From Basic Science to Clinical Applications
journal, January 2001


Activation of osteo-progenitor cells by a novel synthetic peptide derived from the bone morphogenetic protein-2 knuckle epitope
journal, September 2003


Fibroblasts expressing Sonic hedgehog induce osteoblast differentiation and ectopic bone formation
journal, March 1997


Laparoscopic Anterior Lumbar Interbody Fusion With rhBMP-2: A Prospective Study of Clinical and Radiographic Outcomes
journal, January 2001


Stimulatory Effects of Basic Fibroblast Growth Factor and Bone Morphogenetic Protein-2 on Osteogenic Differentiation of Rat Bone Marrow-Derived Mesenchymal Stem Cells
journal, October 1997


Structure and Sequence of HumanFGF8
journal, July 1996


Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth
journal, August 1989


Semirational design of a potent, artificial agonist of fibroblast growth factor receptors
journal, December 1999

  • Ballinger, Marcus D.; Shyamala, Venkatakrishna; Forrest, Louise D.
  • Nature Biotechnology, Vol. 17, Issue 12, p. 1199-1204
  • https://doi.org/10.1038/70746

A Functional Fibroblast Growth Factor-1 Immunoglobulin Fusion Protein
journal, June 1998


Overview of Bone Morphogenetic Proteins
journal, January 2002


Structure and Expression of the mRNA Encoding a Novel Fibroblast Growth Factor, FGF-18
journal, July 1998


Growing better blood vessels
journal, November 2001


Identification of a novel fibroblast growth factor, FGF-22, preferentially expressed in the inner root sheath of the hair follicle
journal, February 2001


Time for treating bone fracture using rhBMP-2: A randomised placebo controlled mouse fracture trial
journal, May 2005


Specific Activation of the p38 Mitogen-activated Protein Kinase Signaling Pathway and Induction of Neurite Outgrowth in PC12 Cells by Bone Morphogenetic Protein-2
journal, September 1999


Sonic hedgehog is involved in osteoblast differentiation by cooperating with BMP-2
journal, October 2002


The NH2-terminal region of the active domain of sonic hedgehog is necessary for its signal transduction
journal, March 1999


The Mode of Bone Morphogenetic Protein (BMP) Receptor Oligomerization Determines Different BMP-2 Signaling Pathways
journal, November 2001


BMP-2 antagonists emerge from alterations in the low-affinity binding epitope for receptor BMPR-II
journal, July 2000


Alginate hydrogel linked with synthetic oligopeptide derived from BMP-2 allows ectopic osteoinductionin vivo
journal, June 2000


Tandem Ligation of Multipartite Peptides with Cell-Permeable Activity
journal, January 2003


Use of Recombinant Human Bone Morphogenetic Protein-2 in Spinal Fusion Applications
journal, January 2002


Identification of a Novel Fibroblast Growth Factor, FGF-23, Preferentially Expressed in the Ventrolateral Thalamic Nucleus of the Brain
journal, October 2000


BMP signaling components are expressed in human fracture callus
journal, September 2003


Endothelial Apoptosis as the Primary Lesion Initiating Intestinal Radiation Damage in Mice
journal, July 2001


Safety Profile for the Clinical Use of Bone Morphogenetic Proteins in the Spine
journal, January 2002


Design and Chemical Synthesis of a Homogeneous Polymer-Modified Erythropoiesis Protein
journal, February 2003


Prolonged ectopic calcification induced by BMP-2-derived synthetic peptide
journal, January 2004