Compositions and methods related to serotonin 5-HT1A receptors
Abstract
Contemplated substituted arylpiperazinyl compounds, and most preferably .sup.18F-Mefway, exhibit desirable in vitro and in vivo binding characteristics to the 5-HT1A receptor. Among other advantageous parameters, contemplated compounds retain high binding affinity, display optimal lipophilicity, and are radiolabeled efficiently with .sup.18F-fluorine in a single step. Still further, contemplated compounds exhibit high target to non-target ratios in receptor-rich regions both in vitro and in vivo, and selected compounds can be effectively and sensitively displaced by serotonin, thus providing a quantitative tool for measuring 5-HT1A receptors and serotonin concentration changes in the living brain.
- Inventors:
-
- Irvine, CA
- Fresno, CA
- (Fresno, CA)
- Issue Date:
- Research Org.:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1062976
- Patent Number(s):
- RE43,688
- Assignee:
- The Regents of the University of California (Oakland, CA)
- DOE Contract Number:
- FG03-02ER63294
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES
Citation Formats
Mukherjee, Jogeshwar, Saigal, Neil, and Saigal, legal representative, Harsh. Compositions and methods related to serotonin 5-HT1A receptors. United States: N. p., 2012.
Web.
Mukherjee, Jogeshwar, Saigal, Neil, & Saigal, legal representative, Harsh. Compositions and methods related to serotonin 5-HT1A receptors. United States.
Mukherjee, Jogeshwar, Saigal, Neil, and Saigal, legal representative, Harsh. Tue .
"Compositions and methods related to serotonin 5-HT1A receptors". United States. https://www.osti.gov/servlets/purl/1062976.
@article{osti_1062976,
title = {Compositions and methods related to serotonin 5-HT1A receptors},
author = {Mukherjee, Jogeshwar and Saigal, Neil and Saigal, legal representative, Harsh},
abstractNote = {Contemplated substituted arylpiperazinyl compounds, and most preferably .sup.18F-Mefway, exhibit desirable in vitro and in vivo binding characteristics to the 5-HT1A receptor. Among other advantageous parameters, contemplated compounds retain high binding affinity, display optimal lipophilicity, and are radiolabeled efficiently with .sup.18F-fluorine in a single step. Still further, contemplated compounds exhibit high target to non-target ratios in receptor-rich regions both in vitro and in vivo, and selected compounds can be effectively and sensitively displaced by serotonin, thus providing a quantitative tool for measuring 5-HT1A receptors and serotonin concentration changes in the living brain.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Sep 25 00:00:00 EDT 2012},
month = {Tue Sep 25 00:00:00 EDT 2012}
}
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