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Title: Method and apparatus for combinatorial chemistry

Abstract

A method and apparatus are provided for performing light-directed reactions in spatially addressable channels within a plurality of channels. One aspect of the invention employs photoactivatable reagents in solutions disposed into spatially addressable flow streams to control the parallel synthesis of molecules immobilized within the channels. The reagents may be photoactivated within a subset of channels at the site of immobilized substrate molecules or at a light-addressable site upstream from the substrate molecules. The method and apparatus of the invention find particularly utility in the synthesis of biopolymer arrays, e.g., oligonucleotides, peptides and carbohydrates, and in the combinatorial synthesis of small molecule arrays for drug discovery.

Inventors:
 [1]
  1. Oak Ridge, TN
Issue Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1055721
Patent Number(s):
8193336
Application Number:
12/488,242
Assignee:
Foote, Robert S. (Oak Ridge, TN)
Patent Classifications (CPCs):
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07H - SUGARS
DOE Contract Number:  
AC05-96OR22464
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Foote, Robert S. Method and apparatus for combinatorial chemistry. United States: N. p., 2012. Web.
Foote, Robert S. Method and apparatus for combinatorial chemistry. United States.
Foote, Robert S. Tue . "Method and apparatus for combinatorial chemistry". United States. https://www.osti.gov/servlets/purl/1055721.
@article{osti_1055721,
title = {Method and apparatus for combinatorial chemistry},
author = {Foote, Robert S},
abstractNote = {A method and apparatus are provided for performing light-directed reactions in spatially addressable channels within a plurality of channels. One aspect of the invention employs photoactivatable reagents in solutions disposed into spatially addressable flow streams to control the parallel synthesis of molecules immobilized within the channels. The reagents may be photoactivated within a subset of channels at the site of immobilized substrate molecules or at a light-addressable site upstream from the substrate molecules. The method and apparatus of the invention find particularly utility in the synthesis of biopolymer arrays, e.g., oligonucleotides, peptides and carbohydrates, and in the combinatorial synthesis of small molecule arrays for drug discovery.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2012},
month = {6}
}

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Works referenced in this record:

A general and expedient method for the solid-phase synthesis of 1,4-benzodiazepine derivatives
journal, December 1992


"Analogous" Organic Synthesis of Small-Compound Libraries: Validation of Combinatorial Chemistry in Small-Molecule Synthesis
journal, March 1994


Advances in genosensor research
journal, May 1995


A General Method for Molecular Tagging of Encoded Combinatorial Chemistry Libraries
journal, August 1994


Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid.
journal, July 1984


Light-directed, spatially addressable parallel chemical synthesis
journal, February 1991


The combinatorial synthesis and chemical and biological evaluation of a 1,4-benzodiazepine library.
journal, May 1994


General method for rapid synthesis of multicomponent peptide mixtures
journal, June 1991


Small peptides induce antibodies with a sequence and structural requirement for binding antigen comparable to antibodies raised against the native protein.
journal, January 1985


The p-nitrophenylethyl (NPE) group
journal, January 1984


DNA sequence determination by hybridization: a strategy for efficient large-scale sequencing
journal, June 1993


Oligonucleotide Synthesis Using Solution Photogenerated Acids
journal, December 1998


Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery
journal, November 1991


Acetalins: opioid receptor antagonists determined through the use of synthetic peptide combinatorial libraries.
journal, November 1993


"Diversomers": an approach to nonpeptide, nonoligomeric chemical diversity.
journal, August 1993