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Title: Annexin A9 (ANXA9) biomarker and therapeutic target in epithelial cancer

Abstract

Amplification of the ANXA9 gene in human chromosomal region 1q21 in epithelial cancers indicates a likelihood of both in vivo drug resistance and metastasis, and serves as a biomarker indicating these aspects of the disease. ANXA9 can also serve as a therapeutic target. Interfering RNAs (iRNAs) (such as siRNA and miRNA) and shRNA adapted to inhibit ANXA9 expression, when formulated in a therapeutic composition, and delivered to cells of the tumor, function to treat the epithelial cancer.

Inventors:
 [1];  [2];  [3];  [4]
  1. El Cerrito, CA
  2. San Ramon, CA
  3. San Mateo, CA
  4. San Francisco, CA
Issue Date:
Research Org.:
University of California (Oakland, CA)
Sponsoring Org.:
USDOE
OSTI Identifier:
1055690
Patent Number(s):
8198254
Application Number:
12/412,304
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
DOE Contract Number:  
AC02-05CH11231
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Hu, Zhi, Kuo, Wen-Lin, Neve, Richard M, and Gray, Joe W. Annexin A9 (ANXA9) biomarker and therapeutic target in epithelial cancer. United States: N. p., 2012. Web.
Hu, Zhi, Kuo, Wen-Lin, Neve, Richard M, & Gray, Joe W. Annexin A9 (ANXA9) biomarker and therapeutic target in epithelial cancer. United States.
Hu, Zhi, Kuo, Wen-Lin, Neve, Richard M, and Gray, Joe W. Tue . "Annexin A9 (ANXA9) biomarker and therapeutic target in epithelial cancer". United States. https://www.osti.gov/servlets/purl/1055690.
@article{osti_1055690,
title = {Annexin A9 (ANXA9) biomarker and therapeutic target in epithelial cancer},
author = {Hu, Zhi and Kuo, Wen-Lin and Neve, Richard M and Gray, Joe W},
abstractNote = {Amplification of the ANXA9 gene in human chromosomal region 1q21 in epithelial cancers indicates a likelihood of both in vivo drug resistance and metastasis, and serves as a biomarker indicating these aspects of the disease. ANXA9 can also serve as a therapeutic target. Interfering RNAs (iRNAs) (such as siRNA and miRNA) and shRNA adapted to inhibit ANXA9 expression, when formulated in a therapeutic composition, and delivered to cells of the tumor, function to treat the epithelial cancer.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2012},
month = {6}
}

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