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Title: Assay for vitamin B12 absorption and method of making labeled vitamin B12

Abstract

The invention provides methods for labeling vitamin B12 with .sup.14C, .sup.13C, tritium, and deuterium. When radioisotopes are used, the invention provides for methods of labeling B12 with high specific activity. The invention also provides labeled vitamin B12 compositions made in accordance with the invention.

Inventors:
 [1];  [1];  [1];  [2];  [1];  [3];  [4]
  1. Davis, CA
  2. Elmacero, CA
  3. Silver Spring, MD
  4. Orinda, CA
Issue Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1055506
Patent Number(s):
8202507
Application Number:
11/234,079
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Anderson, Peter J, Dueker, Stephen, Miller, Joshua, Green, Ralph, Roth, John, Carkeet, Colleen, and Buchholz, Bruce A. Assay for vitamin B12 absorption and method of making labeled vitamin B12. United States: N. p., 2012. Web.
Anderson, Peter J, Dueker, Stephen, Miller, Joshua, Green, Ralph, Roth, John, Carkeet, Colleen, & Buchholz, Bruce A. Assay for vitamin B12 absorption and method of making labeled vitamin B12. United States.
Anderson, Peter J, Dueker, Stephen, Miller, Joshua, Green, Ralph, Roth, John, Carkeet, Colleen, and Buchholz, Bruce A. Tue . "Assay for vitamin B12 absorption and method of making labeled vitamin B12". United States. https://www.osti.gov/servlets/purl/1055506.
@article{osti_1055506,
title = {Assay for vitamin B12 absorption and method of making labeled vitamin B12},
author = {Anderson, Peter J and Dueker, Stephen and Miller, Joshua and Green, Ralph and Roth, John and Carkeet, Colleen and Buchholz, Bruce A.},
abstractNote = {The invention provides methods for labeling vitamin B12 with .sup.14C, .sup.13C, tritium, and deuterium. When radioisotopes are used, the invention provides for methods of labeling B12 with high specific activity. The invention also provides labeled vitamin B12 compositions made in accordance with the invention.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2012},
month = {6}
}

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Works referenced in this record:

Biosynthesis of the 5,6-dimethylbenzimidazole moiety of vitamin B12
journal, September 1969


Biosynthesis of cobalamin in Salmonella typhimurium : transformation of riboflavin into the 5,6-dimethylbenzimidazole moiety
journal, December 1998