Microfluidic chemical reaction circuits

Lee, Chung-cheng; Sui, Guodong; Elizarov, Arkadij; Kolb, Hartmuth C; Huang, Jiang; Heath, James R; Phelps, Michael E; Quake, Stephen R; Tseng, Hsian-rong; Wyatt, Paul; Daridon, Antoine

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Title: Microfluidic chemical reaction circuits

Abstract

New microfluidic devices, useful for carrying out chemical reactions, are provided. The devices are adapted for on-chip solvent exchange, chemical processes requiring multiple chemical reactions, and rapid concentration of reagents.

Inventors:

Lee, Chung-cheng ^[1]; Sui, Guodong ^[2]; Elizarov, Arkadij ^[3]; Kolb, Hartmuth C ^[4]; Huang, Jiang ^[5]; Heath, James R ^[6]; Phelps, Michael E ^[2]; Quake, Stephen R ^[7]; Tseng, Hsian-rong ^[2]; Wyatt, Paul ^[8]; Daridon, Antoine ^[9]

Irvine, CA
Los Angeles, CA
Valley Village, CA
Playa del Rey, CA
San Jose, CA
South Pasadena, CA
Stanford, CA
Tipperary, IE
Mont-Sur-Rolle, CH

Issue Date:: Tue Jun 26 00:00:00 EDT 2012

Research Org.:: Fluidigm Corporation (So. San Francisco, CA); California Institute of Technology (CalTech), Pasadena, CA (United States); Univ. of California, Oakland, CA (United States); Siemens Medical Solutions USA, Inc. (Malvern, PA)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1055441

Patent Number(s):: 8206593

Application Number:: US patent applicaiton 11/792,168

Assignee:: Fluidigm Corporation (So. San Francisco, CA); California Institute of Technology (Pasadena, CA); The Regents of the University of California (Oakland, CA); Siemens Medical Solutions USA, Inc. (Malvern, PA)

Patent Classifications (CPCs):: B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01F - MIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY

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B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01F - MIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
B01F2215/0404 - theories or general explanations of phenomena associated with mixing or generalizations of a concept by comparison of equivalent methods

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
B01J19/0093 - {Microreactors, e.g. miniaturised or microfabricated reactors
B01J2219/00286 - Reactor vessels with top and bottom openings
B01J2219/00396 - Membrane valves
B01J2219/00398 - in multiple arrangements
B01J2219/00414 - using suction
B01J2219/00418 - using pressure
B01J2219/00495 - Means for heating or cooling the reaction vessels
B01J2219/00585 - Parallel processes
B01J2219/00599 - Solution-phase processes
B01J2219/00731 - Saccharides
B01J2219/00759 - Purification of compounds synthesised
B01J2219/00783 - Laminate assemblies, i.e. the reactor comprising a stack of plates
B01J2219/00822 - Metal
B01J2219/00824 - Ceramic
B01J2219/00828 - Silicon wafers or plates
B01J2219/00831 - Glass
B01J2219/00833 - Plastic
B01J2219/0086 - Dimensions of the flow channels
B01J2219/00873 - Heat exchange
B01J2219/00889 - Mixing
B01J2219/00891 - Feeding or evacuation
B01J2219/00907 - using membranes

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
B01L3/5027 - {by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip

B - PERFORMING OPERATIONS B33 - ADDITIVE MANUFACTURING TECHNOLOGY B33Y - ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
B33Y80/00 - Products made by additive manufacturing

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07B - GENERAL METHODS OF ORGANIC CHEMISTRY
C07B59/00 - Introduction of isotopes of elements into organic compounds {

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DOE Contract Number:: FC02-02ER63420

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats


                    Lee, Chung-cheng, Sui, Guodong, Elizarov, Arkadij, Kolb, Hartmuth C, Huang, Jiang, Heath, James R, Phelps, Michael E, Quake, Stephen R, Tseng, Hsian-rong, Wyatt, Paul, and Daridon, Antoine. Microfluidic chemical reaction circuits.  United States: N. p., 2012. 
        Web.

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                    Lee, Chung-cheng, Sui, Guodong, Elizarov, Arkadij, Kolb, Hartmuth C, Huang, Jiang, Heath, James R, Phelps, Michael E, Quake, Stephen R, Tseng, Hsian-rong, Wyatt, Paul, & Daridon, Antoine. Microfluidic chemical reaction circuits.  United States.

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                    Lee, Chung-cheng, Sui, Guodong, Elizarov, Arkadij, Kolb, Hartmuth C, Huang, Jiang, Heath, James R, Phelps, Michael E, Quake, Stephen R, Tseng, Hsian-rong, Wyatt, Paul, and Daridon, Antoine. Tue .  
        "Microfluidic chemical reaction circuits".  United States.  https://www.osti.gov/servlets/purl/1055441.

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@article{osti_1055441,

  title        = {Microfluidic chemical reaction circuits},

  author       = {Lee, Chung-cheng and Sui, Guodong and Elizarov, Arkadij and Kolb, Hartmuth C and Huang, Jiang and Heath, James R and Phelps, Michael E and Quake, Stephen R and Tseng, Hsian-rong and Wyatt, Paul and Daridon, Antoine},

  abstractNote = {New microfluidic devices, useful for carrying out chemical reactions, are provided. The devices are adapted for on-chip solvent exchange, chemical processes requiring multiple chemical reactions, and rapid concentration of reagents.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Jun 26 00:00:00 EDT 2012},

  month        = {Tue Jun 26 00:00:00 EDT 2012}

}

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Size-Controlled Growth of CdSe Nanocrystals in Microfluidic Reactors
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Similar Records

Title: Microfluidic chemical reaction circuits

Abstract

Citation Formats

Microreactors, a new efficient tool for optimum reactor design journal, February 2001

Positron emission tomography provides molecular imaging of biological processes journal, August 2000

Microreactor Technology: A Revolution for the Fine Chemical and Pharmaceutical Industries? journal, March 2005

Room-Temperature Swern Oxidations by Using a Microscale Flow System journal, April 2005

Solvent-Resistant Photocurable “Liquid Teflon” for Microfluidic Device Fabrication journal, March 2004

Micro Total Analysis Systems. Recent Developments journal, June 2004

Focus journal, January 2002

Multistep Synthesis of a Radiolabeled Imaging Probe Using Integrated Microfluidics journal, December 2005

A Microfluidic Device for Conducting Gas-Liquid-Solid Hydrogenation Reactions journal, May 2004

Microfluidic Large-Scale Integration journal, September 2002

Syntheses of 11C- and 18F-labeled carboxylic esters within a hydrodynamically-driven micro-reactor journal, January 2004

Size-Controlled Growth of CdSe Nanocrystals in Microfluidic Reactors journal, February 2003

Chemistry in Microstructured Reactors journal, January 2004

Micro reactors: principles and applications in organic synthesis journal, June 2002

A Microfabricated Rotary Pump journal, January 2001

Microfluidic combinatorial chemistry journal, June 2003

Micro-Flow Reaction Systems for Combinatorial Syntheses journal, January 2004

Electronic Generators book, January 2004

A nanoliter-scale nucleic acid processor with parallel architecture journal, March 2004

Microreactors, a new efficient tool for optimum reactor design
journal, February 2001

Positron emission tomography provides molecular imaging of biological processes
journal, August 2000

Microreactor Technology: A Revolution for the Fine Chemical and Pharmaceutical Industries?
journal, March 2005

Room-Temperature Swern Oxidations by Using a Microscale Flow System
journal, April 2005

Solvent-Resistant Photocurable “Liquid Teflon” for Microfluidic Device Fabrication
journal, March 2004

Micro Total Analysis Systems. Recent Developments
journal, June 2004

Focus
journal, January 2002

Multistep Synthesis of a Radiolabeled Imaging Probe Using Integrated Microfluidics
journal, December 2005

A Microfluidic Device for Conducting Gas-Liquid-Solid Hydrogenation Reactions
journal, May 2004

Microfluidic Large-Scale Integration
journal, September 2002

Syntheses of 11C- and 18F-labeled carboxylic esters within a hydrodynamically-driven micro-reactor
journal, January 2004

Size-Controlled Growth of CdSe Nanocrystals in Microfluidic Reactors
journal, February 2003

Chemistry in Microstructured Reactors
journal, January 2004

Micro reactors: principles and applications in organic synthesis
journal, June 2002

A Microfabricated Rotary Pump
journal, January 2001

Microfluidic combinatorial chemistry
journal, June 2003

Micro-Flow Reaction Systems for Combinatorial Syntheses
journal, January 2004

Electronic Generators
book, January 2004

A nanoliter-scale nucleic acid processor with parallel architecture
journal, March 2004