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Title: Laser diode package with enhanced cooling

Abstract

This invention provides a new method for rapidly analyzing single bioparticles to assess their material condition and state of health. The method is enabled by use of a resonant cavity apparatus to measure an optical property related to the bioparticle size and refractive index. Measuring the refractive index is useful for determining material properties of the bioparticle. The material properties depend on the biomolecular composition of the bioparticle. The biomolecular composition is, in turn, dependent on the state of health of the bioparticle. Thus, measured optical properties can be used to differentiate normal (healthy) and abnormal (diseased) states of bioparticles derived from cells or tissues. The method is illustrated with data obtained from a resonator with a gain medium. The invention also provides new methods for making multiple measurements in a single device and detecting, analyzing, and manipulating bioparticles that are much smaller than the wavelength of light.

Inventors:
; ;
Issue Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1054073
Patent Number(s):
8208509
Application Number:
12/034,640
Assignee:
Lawrence Livermore National Security, LLC (Livermore, CA)
Patent Classifications (CPCs):
H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01S - DEVICES USING THE PROCESS OF LIGHT AMPLIFICATION BY STIMULATED EMISSION OF RADIATION [LASER] TO AMPLIFY OR GENERATE LIGHT
DOE Contract Number:  
AC52-07NA27344
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Deri, Robert J, Kotovsky, Jack, and Spadaccini, Christopher M. Laser diode package with enhanced cooling. United States: N. p., 2012. Web.
Deri, Robert J, Kotovsky, Jack, & Spadaccini, Christopher M. Laser diode package with enhanced cooling. United States.
Deri, Robert J, Kotovsky, Jack, and Spadaccini, Christopher M. Tue . "Laser diode package with enhanced cooling". United States. https://www.osti.gov/servlets/purl/1054073.
@article{osti_1054073,
title = {Laser diode package with enhanced cooling},
author = {Deri, Robert J and Kotovsky, Jack and Spadaccini, Christopher M},
abstractNote = {This invention provides a new method for rapidly analyzing single bioparticles to assess their material condition and state of health. The method is enabled by use of a resonant cavity apparatus to measure an optical property related to the bioparticle size and refractive index. Measuring the refractive index is useful for determining material properties of the bioparticle. The material properties depend on the biomolecular composition of the bioparticle. The biomolecular composition is, in turn, dependent on the state of health of the bioparticle. Thus, measured optical properties can be used to differentiate normal (healthy) and abnormal (diseased) states of bioparticles derived from cells or tissues. The method is illustrated with data obtained from a resonator with a gain medium. The invention also provides new methods for making multiple measurements in a single device and detecting, analyzing, and manipulating bioparticles that are much smaller than the wavelength of light.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2012},
month = {6}
}

Patent:

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Works referenced in this record:

Refractometry and Interferometry of Living Cells*†
journal, January 1957


Optical phenotyping of human mitochondria in a biocavity laser
journal, July 2005


Brief Overview of BioMicroNano Technologies
journal, January 2005


Biocavity laser for high-speed cell and tumour biology
journal, July 2003


Absorption measurements of a cell monolayer relevant to phototherapy: Reduction of cytochrome c oxidase under near IR radiation
journal, November 2005