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Title: Nanolaser spectroscopy and micro-optical resonators for detecting, analyzing, and manipulating bioparticles

Abstract

This invention provides a new method for rapidly analyzing single bioparticles to assess their material condition and state of health. The method is enabled by use of a resonant cavity apparatus to measure an optical property related to the bioparticle size and refractive index. Measuring the refractive index is useful for determining material properties of the bioparticle. The material properties depend on the biomolecular composition of the bioparticle. The biomolecular composition is, in turn, dependent on the state of health of the bioparticle. Thus, measured optical properties can be used to differentiate normal (healthy) and abnormal (diseased) states of bioparticles derived from cells or tissues. The method is illustrated with data obtained from a resonator with a gain medium. The invention also provides new methods for making multiple measurements in a single device and detecting, analyzing, and manipulating bioparticles that are much smaller than the wavelength of light.

Inventors:
Issue Date:
Research Org.:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1054072
Patent Number(s):
8209128
Application Number:
12/034,640
Assignee:
Gourley, Paul L., Albuquerque, NM (United States)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
Resource Type:
Patent
Resource Relation:
Patent File Date: 2008 Feb 20
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Gourley, Paul L. Nanolaser spectroscopy and micro-optical resonators for detecting, analyzing, and manipulating bioparticles. United States: N. p., 2012. Web.
Gourley, Paul L. Nanolaser spectroscopy and micro-optical resonators for detecting, analyzing, and manipulating bioparticles. United States.
Gourley, Paul L. Tue . "Nanolaser spectroscopy and micro-optical resonators for detecting, analyzing, and manipulating bioparticles". United States. https://www.osti.gov/servlets/purl/1054072.
@article{osti_1054072,
title = {Nanolaser spectroscopy and micro-optical resonators for detecting, analyzing, and manipulating bioparticles},
author = {Gourley, Paul L.},
abstractNote = {This invention provides a new method for rapidly analyzing single bioparticles to assess their material condition and state of health. The method is enabled by use of a resonant cavity apparatus to measure an optical property related to the bioparticle size and refractive index. Measuring the refractive index is useful for determining material properties of the bioparticle. The material properties depend on the biomolecular composition of the bioparticle. The biomolecular composition is, in turn, dependent on the state of health of the bioparticle. Thus, measured optical properties can be used to differentiate normal (healthy) and abnormal (diseased) states of bioparticles derived from cells or tissues. The method is illustrated with data obtained from a resonator with a gain medium. The invention also provides new methods for making multiple measurements in a single device and detecting, analyzing, and manipulating bioparticles that are much smaller than the wavelength of light.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2012},
month = {6}
}

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Works referenced in this record:

Refractometry and Interferometry of Living Cells*†
journal, January 1957


Optical phenotyping of human mitochondria in a biocavity laser
journal, July 2005


Brief Overview of BioMicroNano Technologies
journal, January 2005


Biocavity laser for high-speed cell and tumour biology
journal, July 2003


Absorption measurements of a cell monolayer relevant to phototherapy: Reduction of cytochrome c oxidase under near IR radiation
journal, November 2005